2.3.1.260: tetracycline polyketide synthase

This is an abbreviated version!
For detailed information about tetracycline polyketide synthase, go to the full flat file.

Word Map on EC 2.3.1.260

2.3.1.260

ketosynthase

ketoreductase

actinorhodin

malonylation

tetracenomycin

decaketide

self-malonylation

glaucescens

mcats

benzoisochromanequinones

aromatases

holo-acps

Reaction

+ 8 malonyl-CoA =

18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein]

+ 8 CO2 + 8 CoA

Synonyms

minimal PKS, octaketide minimal PKS, otc PKS, oxy, OxyA, oxyABC, OxyB, OxyC, oxytetracycline PKS, oxytetracycline polyketide synthase, type II minimal polyketide synthase, type II PKS

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.260 tetracycline polyketide synthase

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Results	in table
5	AA Sequence
1	Cloned(Commentary)
2	General Information
4	Natural Substrates/ Products (Substrates)
6	Organism
5	Pathway
1	Purification (Commentary)
1	Reaction
6	Reference
5	Substrates and Products (Substrate)
21	Synonyms
1	Systematic Name

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Substrates Products on EC 2.3.1.260 - tetracycline polyketide synthase

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malonamoyl-[OxyC acyl-carrier protein] + malonyl-CoA

18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + CO2 + CoA

3 entries

additional information

Streptomyces rimosus

the enzyme is intrinsically capable of synthesizing an acetate-derived polyketide backbone that is isosteric with the predicted polyketide backbone precursor of oxytetracycline

740567