2.1.1.366: [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ERG-associated protein with SET domain, ESET, KIAA0067, KMT1E, SETDB1
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.366 - [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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S-adenosyl-L-methionine + [histone H3 peptide 1-15]-L-lysine9
S-adenosyl-L-homocysteine + [histone H3 peptide 1-15]-N6-methyl-L-lysine9
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S-adenosyl-L-methionine + [histone H3 peptide 1-15]-N6,N6-dimethyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3 peptide 1-15]-N6,N6,N6-trimethyl-L-lysine9
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?
S-adenosyl-L-methionine + [histone H3 peptide 1-15]-N6-methyl-L-lysine9
S-adenosyl-L-homocysteine + [histone H3 peptide 1-15]-N6,N6-dimethyl-L-lysine9
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?
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H3K9 methylation by SETDB1 occurs in a distributive manner
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additional information
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ESET can specifically methylate histone H3 while inactive toward histone H2A, H2B and H4
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