2.1.1.366: [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, go to the full flat file.

ERG-associated protein with SET domain, ESET, KIAA0067, KMT1E, SETDB1

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Results	in table
13	AA Sequence
7	Application
2	Cloned(Commentary)
13	Disease/ Diagnostics
15	General Information
1	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
3	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
23	Organism
2	Pathway
2	Protein Variants
1	Reaction
23	Reference
24	Source Tissue
6	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Disease on EC 2.1.1.366 - [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase

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Lung Neoplasms

H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis.

Neoplasm Metastasis

H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis.

Neoplasms

H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis.

[histone h3]-n6,n6-dimethyl-lysine9 n-methyltransferase deficiency

KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation.