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1.14.18.B1: 5,6-dihydroxyindole-2-carboxylic acid oxidase

This is an abbreviated version!
For detailed information about 5,6-dihydroxyindole-2-carboxylic acid oxidase, go to the full flat file.

Word Map on EC 1.14.18.B1

Reaction

5,6-dihydroxyindole-2-carboxylic acid
+
O2
=
indole-5,6-quinone-2-carboxylic acid
 +
H2O

Synonyms

H3K27 demethylase, H3K27me3 histone demethylase, histone demethylase, histone H3K27 demethylase, JmjC domain-containing protein 3, JMJD3, Jumonji domain-containing protein 3, KDM6B, kdm6ba, lysine demethylase 6B, PHD finger protein 8, PHF8

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.B1 5,6-dihydroxyindole-2-carboxylic acid oxidase

Source Tissue

Source Tissue on EC 1.14.18.B1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in the zebrafish lateral line neuromasts
Manually annotated by BRENDA team
epidermal keratinocytes
Manually annotated by BRENDA team
CD4+ cells, expression analysis of enzyme in cells from healthy persons and systemic lupus erythematosus patients: significantly decreased H3K27me3 levels and increased JMJD3 binding are detected within the ITGAL (CD11a) promoter locus in SLE CD4+ T cells compared with those in healthy CD4+ T cells
Manually annotated by BRENDA team