Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.18.B1: 5,6-dihydroxyindole-2-carboxylic acid oxidase

This is an abbreviated version!
For detailed information about 5,6-dihydroxyindole-2-carboxylic acid oxidase, go to the full flat file.

Word Map on EC 1.14.18.B1

Reaction

5,6-dihydroxyindole-2-carboxylic acid
+
O2
=
indole-5,6-quinone-2-carboxylic acid
+
H2O

Synonyms

H3K27 demethylase, H3K27me3 histone demethylase, histone demethylase, histone H3K27 demethylase, JmjC domain-containing protein 3, JMJD3, Jumonji domain-containing protein 3, KDM6B, kdm6ba, lysine demethylase 6B, PHD finger protein 8, PHF8

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.B1 5,6-dihydroxyindole-2-carboxylic acid oxidase

Expression

Expression on EC 1.14.18.B1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upregulation of histone H3K27 demethylase JMJD3 by long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, a kind of non-protein coding transcripts longer than 200 nucleotides. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci. HOTAIR can affect histone H3K27 methylation and its target genes' expression
upregulation of JMJD3 expression in scratch-wounded keratinocytes