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1.14.18.B1: 5,6-dihydroxyindole-2-carboxylic acid oxidase

This is an abbreviated version!
For detailed information about 5,6-dihydroxyindole-2-carboxylic acid oxidase, go to the full flat file.

Word Map on EC 1.14.18.B1

Reaction

5,6-dihydroxyindole-2-carboxylic acid
+
O2
=
indole-5,6-quinone-2-carboxylic acid
 +
H2O

Synonyms

H3K27 demethylase, H3K27me3 histone demethylase, histone demethylase, histone H3K27 demethylase, JmjC domain-containing protein 3, JMJD3, Jumonji domain-containing protein 3, KDM6B, kdm6ba, lysine demethylase 6B, PHD finger protein 8, PHF8

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.B1 5,6-dihydroxyindole-2-carboxylic acid oxidase

Cloned

Cloned on EC 1.14.18.B1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene KDM6B or JMJD3, quantitative PCR enzyme expression analysis
overexpression of JMJD3 through the transfection of pcDNA3.1-JMJD3 into healthy donor CD4+ T cells leading to an increase in JMJD3 enrichment, a decrease in H3K27me3 enrichment within the ITGAL (CD11a) promoter, and upregulation of CD11a expression, resulting in T and B cell hyperactivity