1.14.14.89: 4'-methoxyisoflavone 2'-hydroxylase

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For detailed information about 4'-methoxyisoflavone 2'-hydroxylase, go to the full flat file.

Reaction

Synonyms

daidzein and genistein reductase, dgr, EC 1.14.13.53, isoflavone 2'-hydroxylase, isoflavone 2'-monooxygenase, S-DGR

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.89 4'-methoxyisoflavone 2'-hydroxylase

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Results	in table
4	Activating Compound
3	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
3	Cofactor
9	Inhibitors
2	KM Value [mM]
5	Localization
1	Metals/Ions
7	Natural Substrates/ Products (Substrates)
7	Organism
5	Pathway
4	pH Optimum
1	Protein Variants
1	Reaction
4	Reaction Type
7	Reference
6	Source Tissue
1	Storage Stability
25	Substrates and Products (Substrate)
8	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.14.89 - 4'-methoxyisoflavone 2'-hydroxylase

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SYSTEMATIC NAME

IUBMB Comments

formononetin,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)

A cytochrome P-450 (heme-thiolate) protein. Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.14.90, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.