1.14.14.89: 4'-methoxyisoflavone 2'-hydroxylase
This is an abbreviated version!
For detailed information about 4'-methoxyisoflavone 2'-hydroxylase, go to the full flat file.
Reaction
Synonyms
daidzein and genistein reductase, dgr, EC 1.14.13.53, isoflavone 2'-hydroxylase, isoflavone 2'-monooxygenase, S-DGR
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.89 - 4'-methoxyisoflavone 2'-hydroxylase
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REACTION DIAGRAM
biochanin A + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxybiochanin A + [oxidized NADPH-hemoprotein reductase] + H2O
daidzein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxydaidzein + [oxidized NADPH-hemoprotein reductase] + H2O
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
genistein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O
2'-hydroxybiochanin A + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
-
?
biochanin A + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxybiochanin A + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
ir
biochanin A + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxybiochanin A + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
ir
2'-hydroxydaidzein + [oxidized NADPH-hemoprotein reductase] + H2O
-
2.0% of the activity with biochanin A
-
-
?
daidzein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxydaidzein + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
ir
daidzein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxydaidzein + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
ir
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
involved in the biosynthesis of the pterocarpin phytoalexin medicarpin
-
-
?
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
involved in the biosynthesis of the pterocarpin phytoalexin medicarpin
-
-
ir
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
cytochrome P450-dependent monooxygenase
-
-
?
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
cytochrome P450-dependent monooxygenase
-
-
ir
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
78.1% of the activity with biochanin A
-
-
?
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
ir
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
cytochrome P450-dependent monooxygenase
-
-
ir
formononetin + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxyformononetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
ir
2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O
-
2.2% of the activity with biochanin A
-
-
?
genistein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
genistein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
ir
genistein + [reduced NADPH-hemoprotein reductase] + O2
2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
?
-
-
monohydroxylation of 4'-methoxyisoflavones, no substrates are genistein and daidzein
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-
?
additional information
?
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-
monohydroxylation of 4'-methoxyisoflavones, no substrates are genistein and daidzein
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-
?
additional information
?
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-
no substrates are 5,7,4'-trihydroxyflavone, 7,4'-dihydroxyflavone, trans-cinnamic acid and 4-coumaric acid
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-
?
additional information
?
-
reduction of soy isoflavones daidzein and genistein under aerobic conditions by use of the recombinant Escherichia coli whole-cell expressing isoflavone reductase
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-
?