1.14.14.168: germacrene A acid 8beta-hydroxylase

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For detailed information about germacrene A acid 8beta-hydroxylase, go to the full flat file.

Reaction

8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate

Synonyms

CYP71BL1, CYP71BL6, GAA 8beta-hydroxylase, GAA 8x03-hydroxylase, HaG8H

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.168 germacrene A acid 8beta-hydroxylase

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Results	in table
2	AA Sequence
3	Cloned(Commentary)
3	Cofactor
3	General Information
4	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reference
4	Source Tissue
8	Substrates and Products (Substrate)
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.14.168 - germacrene A acid 8beta-hydroxylase

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germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (8beta-hydroxylating)

A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8beta) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8alpha-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170 8-epi-inunolide synthase).