1.14.14.161: nepetalactol monooxygenase

This is an abbreviated version!
For detailed information about nepetalactol monooxygenase, go to the full flat file.

Reaction

+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =

+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

7-deoxyloganetic acid synthase, 7-deoxyloganic acid synthase, 7DLS, CYP76A26, iridoid oxidase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.161 nepetalactol monooxygenase

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Systematic Name on EC 1.14.14.161 - nepetalactol monooxygenase

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(+)-cis,trans-nepetalactol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme thiolate) protein. It catalyses three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.