1.14.14.154: sterol 14alpha-demethylase

This is an abbreviated version!
For detailed information about sterol 14alpha-demethylase, go to the full flat file.

Reaction

Synonyms

14-alpha sterol demethylase, 14-demethylase, 14alpha-demethylase, 14alpha-lanosterol demethylase, 14alpha-methylsterol 14alpha-demethylase, 14alpha-sterol demethylase, 14DM, AF_14DM, C- I4 demethylase, CACYP51, CA_14DM, CYP51, Cyp51A, CYP51A1, CYP51Ap, CYP51B, CYP51b1, CYP51Bp, CYP51F1, CYP51G1, CYPL1, cytochrome CYP51, cytochrome P 450 CYP51, cytochrome P-450 lanosterol 14alpha-demethylase, cytochrome P-450-dependent 14alpha-sterol demethylase, cytochrome P-450-dependent obtusifoliol 14alpha-demethylase, cytochrome P-450/14DM, cytochrome P-45014DM, cytochrome P450 14alpha-demethylase, cytochrome P450 14DM, cytochrome P450 51, cytochrome P450 CYP51, cytochrome P450 lanosterol 14alpha-demethylase, cytochrome P450 sterol 14alpha-demethylase, cytochrome-P450 14alpha-demethylase, demethylase, methylsterol 14alpha-, eburicol 14 alpha-demethylase, eburicol 14alpha-demethylase, EC 1.14.13.70, ERG11, Erg11p, lanosterol 14 alpha-demethylase, lanosterol 14-alpha demethylase, lanosterol 14-demethylase, lanosterol 14alpha-demethylase, lanosterol 14alpha-methyldemethylase, lanosterol C-14 demethylase, lanosterol demethylase, lanosterol-14alpha-demethylase, LDM, methylsterol 14alpha-demethylase (P 450 CYP51), More, Obtusifoliol 14-alpha demethylase, obtusifoliol 14-demethylase, obtusifoliol 14alpha-demethylase, obtusifoliol-metabolizing 14alpha-demethylase, obtusufoliol 14-demethylase, P 450 lanosterol C-14 demethylase, P-450 lanosterol demethylase, P-45014DM, P-45014DM-containing monooxygenase system, P-450OBT 14DM, P450 14alpha-lanosterol demethylases A, P450 14alpha-lanosterol demethylases B, P450(14DM), P450-14DM, P450-L1A1, P45014DM, PCERG11, rLDM, sterol 14-alpha demethylase, sterol 14-demethylase, sterol 14-demethylase P450, sterol 14alpha-demethylase, sterol 14alpha-demethylase (CYP51), sterol 14alpha-demethylase cytochrome P 450, sterol 14alpha-demethylase P450, sterol C14 demethylase, sterol C14-demethylase, sterol demethylase P450, sterol-14alpha-demethylase, TC14DM

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.154 sterol 14alpha-demethylase

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Results	in table
15	Activating Compound
422	AA Sequence
64	Application
4	CAS Registry Number
64	Cloned(Commentary)
115	Cofactor
11	Crystallization (Commentary)
512	Disease/ Diagnostics
5	Expression
24	General Information
3	General Stability
82	IC50 Value
881	Inhibitors
4	kcat/KM [mM/s]
38	KM Value [mM]
74	Localization
21	Metals/Ions
23	Molecular Weight [Da]
221	Natural Substrates/ Products (Substrates)
311	Organism
13	Pathway
4	PDB ID
15	pH Optimum
1	pH Range
4	pI Value
3	Posttranslational Modification
76	Protein Variants
29	Purification (Commentary)
18	Reaction
7	Reaction Type
186	Reference
69	Source Tissue
23	Specific Activity [micromol/min/mg]
2	Storage Stability
470	Substrates and Products (Substrate)
37	Subunits
303	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Organism

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Organism on EC 1.14.14.154 - sterol 14alpha-demethylase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acanthamoeba polyphaga

-

671727

-

-

brenda

Arabidopsis thaliana

-

285344

-

-

brenda

Aspergillus flavus

voriconazole-resistant clinical isolates and voriconazole-susceptible parent strain X26728

704035

-

-

brenda

Aspergillus fumigatus

4 entries

Aspergillus fumigatus Af293

isozymes CYP51A and CYP51B, i.e. AF51A and AF51B

710892

-

-

brenda

Blumeria graminis

2 entries

Bos taurus

2 entries

Candida albicans

8 entries

Candida albicans ATCC 7661

strain ATCC7661

703550

-

-

brenda

Candida albicans ATCC MYA-2876

-

726803

P10613

Swissprot

brenda

Candida albicans SC5314

-

744860, 745117

P10613

SwissProt

brenda

Candida parapsilosis

-

672607, 673445, 703550

-

-

brenda

Candida tropicalis

-

285344, 285348, 285352, 285354, 673445, 703550

-

-

brenda

Cryptococcus neoformans

3 entries

Danio rerio

-

744385

-

-

brenda

Embryophyta

higher plants

285346, 285348, 285350, 285354

-

-

brenda

Fonsecaea compacta

-

673445

-

-

brenda

Gallus gallus

2 entries

Homo sapiens

4 entries

Leishmania infantum

-

727880, 744843

A2TEF2

UniProt

brenda

Leishmania major

-

744843

-

-

brenda

Leishmania mexicana

-

744843

-

-

brenda

Malassezia globosa

-

746454

A8Q3I7

UniProt

brenda

Malassezia globosa CBS 7966

-

746454

A8Q3I7

UniProt

brenda

Manihot esculenta

Crantz

285344

-

-

brenda

Methylococcus capsulatus

-

671727, 672414

-

-

brenda

Microsporum canis

-

672607

-

-

brenda

Monilinia fructicola

fragment; field isolates from Georgia, which are demethylation inhibitor fungicides-sensitive or demethylation inhibitor fungicides-resistant, gene CYP51

684580

A7LM25

UniProt

brenda

Mus musculus

-

658561, 659942, 688999, 702509, 706694

-

-

brenda

Mycobacterium avium subsp. avium

-

671268

Q3HTM1

SwissProt

brenda

Mycobacterium tuberculosis

10 entries

Mycobacterium tuberculosis H37Rv

-

659513, 684486, 687710, 701593, 705342, 728050

P9WPP9

Uniprot

brenda

Mycolicibacterium smegmatis

-

672414

-

-

brenda

Nannizzia gypsea

-

673445, 703550

-

-

brenda

Nicotiana benthamiana

silencing of enzyme by potato virus X::Nt CYP51-1 transcripts, accumulation of obtusifoliol

659601

-

-

brenda

no activity in Escherichia coli

no endogenous sterol 14alpha-demethylase

285344

-

-

brenda

Oculimacula acuformis

syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51

671942

-

-

brenda

Oculimacula yallundae

syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51

671942

-

-

brenda

Ovis aries

ram

658561

-

-

brenda

Penicillium digitatum

2 entries

Penicillium italicum

3 entries

Phanerodontia chrysosporium

-

705462

Q68HC3

UniProt

brenda

Pichia kudriavzevii

-

703550

-

-

brenda

Pneumocystis carinii

-

657522

-

-

brenda

Pneumocystis jirovecii

28 different species isolated from human lung

675115

-

-

brenda

Pyricularia grisea

-

706082

-

-

brenda

Pyricularia oryzae

-

727582

-

-

brenda

Pyricularia oryzae Guy11

-

727582

-

-

brenda

Rattus norvegicus

6 entries

Saccharomyces cerevisiae

3 entries

Saccharomyces cerevisiae BY4741

-

701727

-

-

brenda

Saccharomyces cerevisiae FY1679

-

672337

-

-

brenda

Saccharomyces cerevisiae YJM789

-

746216

A6ZSR0

UniProt

brenda

Schizosaccharomyces pombe

-

285344, 285354

-

-

brenda

Sinapis alba

L.

285344

-

-

brenda

Sinapis alba L.

L.

285344

-

-

brenda

Solanum chacoense

gene CYP51

676589

Q673E9

SwissProt

brenda

Sorghum bicolor

2 entries

Streptomyces coelicolor

expression in Escherichia coli with tetrahistidine tag

657808

-

-

brenda

Taiwanofungus camphoratus

i.e. Antrodia camphorata, gene CYP51

712223

A8DBU6

UniProt

brenda

Taiwanofungus camphoratus TFRIB 470

i.e. Antrodia camphorata, gene CYP51

712223

A8DBU6

UniProt

brenda

Trichophyton rubrum

-

672607, 673445, 703550

-

-

brenda

Trypanosoma brucei

-

671727, 672414, 701584

-

-

brenda

Trypanosoma cruzi

4 entries

Trypanosoma cruzi CL Brener

-

745522

Q7Z1V1

SwissProt

brenda

Ustilago maydis

-

285344, 285354, 672414

-

-

brenda

Zea mays

2 entries

Zea mays LG11

LG11

285355

-

-

brenda

Zymoseptoria tritici

3 entries

Zymoseptoria tritici IPO323

gene CYP51

710939

-

-

brenda

[Candida] glabrata

-

285344

-

-

brenda

Aspergillus fumigatus

-

659531, 672607, 673445, 703550

-

-

brenda

Aspergillus fumigatus

gene cyp51A, strain CM-237, and azole-insensitive clinical strains CNM-CM-1252 and CNM-CM-796

671363

-

-

brenda

Aspergillus fumigatus

isoenzymes CYP51A and CYP51B

710895

-

-

brenda

Aspergillus fumigatus

isozymes CYP51A and CYP51B, i.e. AF51A and AF51B

710892

-

-

brenda

Blumeria graminis

f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51

671942

-

-

brenda

Blumeria graminis

f.sp. hordei

658808

-

-

brenda

Bos taurus

-

658561

-

-

brenda

Bos taurus

-

684925

Q4PJW3

Uniprot

brenda

Candida albicans

-

285344, 285348, 285352, 285354

-

-

brenda

Candida albicans

-

659097

P10613

Swissprot

brenda

Candida albicans

-

659531, 671942, 672414, 672607, 673445, 677216, 685453, 701584

-

-

brenda

Candida albicans

-

726803

P10613

Swissprot

brenda

Candida albicans

-

728553

-

-

brenda

Candida albicans

-

745378

Q9P4W0

UniProt

brenda

Candida albicans

-

745682

C8XRD8

SwissProt

brenda

Candida albicans

strain ATCC7661

703550

-

-

brenda

Cryptococcus neoformans

-

672607, 673445

-

-

brenda

Cryptococcus neoformans

-

701738

Q870D1

UniProt

brenda

Cryptococcus neoformans

-

703550

-

-

brenda

Gallus gallus

liver-type enzyme

673147

Q0KKP4

SwissProt

brenda

Gallus gallus

testis-type enzyme

673147

Q0KKP5

SwissProt

brenda

Homo sapiens

-

659513, 671727, 672414, 677216, 685534, 701584

-

-

brenda

Homo sapiens

-

701727, 727052, 744274

Q16850

UniProt

brenda

Homo sapiens

gene CYP51

673347

-

-

brenda

Homo sapiens

human

285344, 285354

-

-

brenda

Mycobacterium tuberculosis

-

659513

P9WPP9

Uniprot

brenda

Mycobacterium tuberculosis

-

671727, 672414

-

-

brenda

Mycobacterium tuberculosis

-

684486

P9WPP9

Uniprot

brenda

Mycobacterium tuberculosis

-

685303

-

-

brenda

Mycobacterium tuberculosis

-

687710

P9WPP9

Uniprot

brenda

Mycobacterium tuberculosis

-

701584

-

-

brenda

Mycobacterium tuberculosis

-

701593, 705342

P9WPP9

Uniprot

brenda

Mycobacterium tuberculosis

-

711171

-

-

brenda

Mycobacterium tuberculosis

-

728050

P9WPP9

Uniprot

brenda

Mycobacterium tuberculosis

gene RV0764c

672195

-

-

brenda

Penicillium digitatum

-

686798

A1XG20

UniProt

brenda

Penicillium digitatum

-

702576

-

-

brenda

Penicillium italicum

-

285354

-

-

brenda

Penicillium italicum

filamentous fungal plant pathogen

285352

-

-

brenda

Penicillium italicum

filamentous fungi

285344

-

-

brenda

Rattus norvegicus

-

285344, 285348

-

-

brenda

Rattus norvegicus

-

285353

Q64654

Uniprot

brenda

Rattus norvegicus

-

672414

-

-

brenda

Rattus norvegicus

male rat

285354

-

-

brenda

Rattus norvegicus

male sprague-dawley rats

285345

-

-

brenda

Rattus norvegicus

Sprague-Dawley rat

285349

-

-

brenda

Saccharomyces cerevisiae

-

285344, 285345, 285346, 285347, 285348, 285351, 285352, 285354, 672337, 672414, 701727

-

-

brenda

Saccharomyces cerevisiae

-

702515

P10614

UniProt

brenda

Saccharomyces cerevisiae

-

746216

A6ZSR0

UniProt

brenda

Sorghum bicolor

-

672414

-

-

brenda

Sorghum bicolor

L., Moench

285344, 285350

-

-

brenda

Trypanosoma cruzi

-

659901, 672414, 675865, 705030

-

-

brenda

Trypanosoma cruzi

-

745522

Q7Z1V1

SwissProt

brenda

Trypanosoma cruzi

gene CYP51

674700, 712461

Q7Z1V1

SwissProt

brenda

Trypanosoma cruzi

strains Tulahuen, Peru, Y, EP, CL, SC-28, Colombiana, Bertoldo, YuYu and VL-10

701584

Q7Z1V1

SwissProt

brenda

Zea mays

LG11

285355

-

-

brenda

Zea mays

maize

285344, 285355

-

-

brenda

Zymoseptoria tritici

-

689083, 726714

-

-

brenda

Zymoseptoria tritici

gene CYP51

710939

-

-

brenda

Zymoseptoria tritici

septoria leaf blotch fungus

671942

-

-

brenda