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1.14.14.154: sterol 14alpha-demethylase

This is an abbreviated version!
For detailed information about sterol 14alpha-demethylase, go to the full flat file.

Word Map on EC 1.14.14.154

Reaction

a 14alpha-formylsteroid
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
a DELTA14-steroid
 +
formate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

14-alpha sterol demethylase, 14-demethylase, 14alpha-demethylase, 14alpha-lanosterol demethylase, 14alpha-methylsterol 14alpha-demethylase, 14alpha-sterol demethylase, 14DM, AF_14DM, C- I4 demethylase, CACYP51, CA_14DM, CYP51, Cyp51A, CYP51A1, CYP51Ap, CYP51B, CYP51b1, CYP51Bp, CYP51F1, CYP51G1, CYPL1, cytochrome CYP51, cytochrome P 450 CYP51, cytochrome P-450 lanosterol 14alpha-demethylase, cytochrome P-450-dependent 14alpha-sterol demethylase, cytochrome P-450-dependent obtusifoliol 14alpha-demethylase, cytochrome P-450/14DM, cytochrome P-45014DM, cytochrome P450 14alpha-demethylase, cytochrome P450 14DM, cytochrome P450 51, cytochrome P450 CYP51, cytochrome P450 lanosterol 14alpha-demethylase, cytochrome P450 sterol 14alpha-demethylase, cytochrome-P450 14alpha-demethylase, demethylase, methylsterol 14alpha-, eburicol 14 alpha-demethylase, eburicol 14alpha-demethylase, EC 1.14.13.70, ERG11, Erg11p, lanosterol 14 alpha-demethylase, lanosterol 14-alpha demethylase, lanosterol 14-demethylase, lanosterol 14alpha-demethylase, lanosterol 14alpha-methyldemethylase, lanosterol C-14 demethylase, lanosterol demethylase, lanosterol-14alpha-demethylase, LDM, methylsterol 14alpha-demethylase (P 450 CYP51), More, Obtusifoliol 14-alpha demethylase, obtusifoliol 14-demethylase, obtusifoliol 14alpha-demethylase, obtusifoliol-metabolizing 14alpha-demethylase, obtusufoliol 14-demethylase, P 450 lanosterol C-14 demethylase, P-450 lanosterol demethylase, P-45014DM, P-45014DM-containing monooxygenase system, P-450OBT 14DM, P450 14alpha-lanosterol demethylases A, P450 14alpha-lanosterol demethylases B, P450(14DM), P450-14DM, P450-L1A1, P45014DM, PCERG11, rLDM, sterol 14-alpha demethylase, sterol 14-demethylase, sterol 14-demethylase P450, sterol 14alpha-demethylase, sterol 14alpha-demethylase (CYP51), sterol 14alpha-demethylase cytochrome P 450, sterol 14alpha-demethylase P450, sterol C14 demethylase, sterol C14-demethylase, sterol demethylase P450, sterol-14alpha-demethylase, TC14DM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.154 sterol 14alpha-demethylase

IC50 Value

IC50 Value on EC 1.14.14.154 - sterol 14alpha-demethylase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0044
3-(alpha-imidazolylbenzyl)indole
Leishmania mexicana
-
pH and temperature not specified in the publication, axenic amastigotes
0.000001
7-chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-4a,8a-dihydroquinazolin-4(3H)-one
Trypanosoma cruzi
strain EP or Y, intracellular amastigote, Vero cell as host cell
0.000002
azalanstat
Rattus norvegicus
specific inhibitor, IC50 less than 0.000002 mM
0.0015 - 0.02
benznidazole
0.0003 - 0.00897
bifonazole
0.000059 - 0.0013
bitertanol
0.0000091 - 0.00281
clotrimazole
0.0001 - 0.0228
cyproconazole
0.00001 - 0.0001
D0870
0.00536 - 0.02
econazole
0.00022 - 0.002
epoxiconazole
0.0322 - 0.1
fadrozole
0.000051 - 0.206
fluconazole
0.000085 - 0.0034
flusilazole
0.000066 - 0.0156
hexaconazole
0.000082 - 0.0361
imazalil
0.000001 - 0.188
itraconazole
0.321
ketaminazole
Malassezia globosa
37°C, pH 7.2
0.000001 - 0.176
ketoconazole
0.0133 - 0.1
letrozole
0.00002 - 0.02
miconazole
0.00014 - 0.029
myclobutanil
0.000076 - 0.0193
penconazole
0.00000025 - 0.0005
posaconazole
0.000098 - 0.005
Prochloraz
0.00015 - 0.0083
Propiconazole
0.0000001 - 0.0001
ravuconazole
0.0000003
TAK-187
Trypanosoma cruzi
strain EP or Y, intracellular amastigote, Vero cell as host cell
0.00035 - 0.0036
tebuconazole
0.00013 - 0.01
triadimefon
0.00033 - 0.0372
triadimenol
0.000004 - 0.03
voriconazole