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14alpha-methylzymosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
(3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
24,25-dihydro-4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
? + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + O2 + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,14,24-triene-3beta-ol + formate + NADP+ + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylzymosterol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
(3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
(3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
(3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
8-lanosta-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
DHL
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
8-lanosten-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
8-lanosta-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
DHL
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
8-lanosten-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
not the natural substrate
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
lanosta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
natural substrate
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
lanosta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
lanosta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
natural substrate
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
lanosta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
P-45014DM catalyzes all three oxygenation steps from lanosterol to dimethylcholestratrienol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
ergosterol synthesis in yeast involves oxidative removal of the 14alpha-methyl group, C-32, of lanosterol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
i.e. lanosta-8,24-dien-3beta-ol
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
deletion of the enzyme is lethal
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
deletion of the enzyme is lethal
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
production of follicular fluid-meiosis activating steroid by lanosterol demethylation
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
production of follicular fluid-meiosis activating steroid by lanosterol demethylation
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM, overview
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is regulated by cholesterol feedback regulation through sterol regulatory element binding proteins, i.e. SREBPs, regulation mechanisms of enzyme expression, overview
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in ergosterol and cholesterol biosynthesis
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
i.e. 4alpha,14alpha-dimethylcholesta-8,24-dien-3beta-ol
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
-
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
i.e. 4alpha,4alpha-dimethylcholesta-8,24-dien-3beta-ol
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
?
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
preferred substrate
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
the enzyme is involved in biosynthesis of sitosterol and brassinosteroids, pathways overview
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
low activity
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
preferred substrate
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4alpha,14alpha-dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4alpha,14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
i.e. 4alpha,14alpha-dimethyl-5'-ergosta-8,24(24')-dien-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4alpha,14alpha-dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4alpha,14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
4alpha,14alpha-dimethyl-24-methylene-5alpha-cholesta-8-en-3beta-ol
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
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4alpha,14alpha-dimethyl-5alpha-ergosta-8,24(28)-dien-3beta-ol
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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14alpha-demethylation is a key step of sterol biosynthesis in eukaryotes
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enzyme of plant sterol, phytosterol, biosynthesis
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housekeeping enzyme essential for viability of mammals, essential step in cholesterol biosynthesis
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of cholesterol biosynthesis
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there is a possibility that P45014DM participates not only in sterol biogenesis but also in production of biosignal substance regulating meiosis of mammalian oocytes
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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CYP51 plays a key role in fertilization by producing intermediates that could serve as ligands for nuclear receptors
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enzyme inhibition may result in endocrine disruption since follicular fluid-meiosis activating steroid, the direct product of lanosterol demethylation, is involved in the control of meiosis
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the enzyme catalyzes a step in the cholesterol biosynthesis via the mevalonate pathway, overview
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CYP51 participates in biosynthesis of cholesterol
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the enzyme is a demethylation inhibitor fungicide resistance determinant in Monilinia fructicola field isolates
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the enzyme is a demethylation inhibitor fungicide resistance determinant in Monilinia fructicola field isolates
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involved in fertilization
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the enzyme is involved in follicle-stimulating hormone-induced mouse oocyte maturation and follicle-stimulating hormone-induced oocyte meiotic resumption, regulation, overview. The enzyme is involved in CREB phosphorylation
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CYP51 is a major checkpoint in membrane sterol biosynthesis, is a key target for fungal antibiotic therapy
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CYP51 is a major checkpoint in membrane sterol biosynthesis, is a key target for fungal antibiotic therapy
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CYP51 is a major checkpoint in membrane sterol biosynthesis, is a key target for fungal antibiotic therapy
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CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs
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CYP51 is one of the key enzymes of sterol biosynthesis in biological kingdoms and is a prime target of antifungal drugs
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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sterol composition of different species isolated from human lung, two distinct sterol compositional phenotypes occur, one, the wild-type, is characterized by DELTA7 C28- and C24 24-alkylsterols with only low proportions of higher molecular mass components, the other type, a mutant with 14alpha-demethylase deficiency, is dominated by high C31 and C32 24-alkylsterols, especially pneumocysterol, NMR sterol analysis, overview
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housekeeping enzyme essential for viability of mammals, essential step in cholesterol biosynthesis
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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brain microsomes, existence of sterol biosynthetic pathway in brain, cholesterol is synthesized de novo in brain
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removal of 14alpha-methyl group, C32, from 14alpha-methylated precursor sterols is an essential step of sterol biosynthesis in eukaryotes
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enzyme of cholesterol biosynthesis
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enzyme of cholesterol biosynthesis
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enzyme of cholesterol biosynthesis
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lanosterol 14-demethylation is situated at the root of sterol-biosynthetic branch of mevalonic acid pathway
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enzyme for regulation of cholesterol biosynthesis
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there is a possibility that P45014DM participates not only in sterol biogenesis but also in production of biosignal substance regulating meiosis of mammalian oocytes
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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removal of 14alpha-methyl group, C32, from 14alpha-methylated precursor sterols is an essential step of sterol biosynthesis in eukaryotes
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enzyme of ergosterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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14alpha-demethylation is a key step of sterol biosynthesis in eukaryotes
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additional information
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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biosynthetic enzyme with very narrow substrate specificity
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biosynthetic enzyme with very narrow substrate specificity
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enzyme is a multifunctional cytochrome P450, which as the same active site catalyze demethylation in three consecutive NADPH- and O2-dependent hydroxylation reactions, resulting in the elimination of the methyl group as formic acid and the introduction of a double bond at the DELTA14 position
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enzyme is a multifunctional cytochrome P450, which as the same active site catalyze demethylation in three consecutive NADPH- and O2-dependent hydroxylation reactions, resulting in the elimination of the methyl group as formic acid and the introduction of a double bond at the DELTA14 position
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catalyzes an essential step in sterol biosynthesis as evidenced by the absence of a 14alpha-methyl group in all known functional sterols, removal of the 14alpha-methyl group is essential
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key enzyme in plant sterol, phytosterol, biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of plant sterol, phytosterol, biosynthesis
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the organism can specifically regulate gene expression, e.g. for the sterol C14-demethylase, in response to derangements in its cellular functions
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enzyme of sterol biosynthesis, sterol 14-demethylation occurs in all organism exhibiting de novo sterol biosynthesis
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of sterol biosynthetic pathway
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enzyme of plant sterol, phytosterol, biosynthesis
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enzyme of plant sterol, phytosterol, biosynthesis
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