Reference on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pegg, A.E.; Williams-Ashman, H.G.
Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate
Biochem. J.
115
241-247
1969
Rattus norvegicus
Carteni'-Farina, M.; Oliva, A.; Romeo, G.; Napolitano, G.; De Rosa, M.; Gambacorta, A.; Zappia, V.
5'-Methylthioadenosine phosphorylase from Caldariella acidophila. Purification and properties
Eur. J. Biochem.
101
317-324
1979
Caldariella acidophila
Garbers, D.L.
Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung
Biochim. Biophys. Acta
523
82-93
1978
Rattus norvegicus
Lee, S.H.; Cho, Y.D.
Purification and properties of 5'-deoxy-5'methylthioadenosine phosphorylase from rat spleen
Korean Biochem. J.
26
433-439
1993
Rattus norvegicus
-
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; Zappia, V.
Thermophilicity and thermostability of 5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
Life Chem. Rep.
10
75-81
1992
Saccharolobus solfataricus
-
Toorchen, D.; Miller, R.L.
Purification and characterization of 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase from human liver
Biochem. Pharmacol.
41
2023-2030
1991
Homo sapiens
Savarese, T.M.; Harrington, S.; Nakamura, C.; Chen, Z.H.; Kumar, P.; Mikkilineni, A.; Abushanab, E.; Chu, S.H.; Parks, R.E.
5'-Deoxy-5'-methylthioadenosine phosphorylase. V. Acycloadenosine derivatives as inhibitors of the enzyme
Biochem. Pharmacol.
40
2465-2471
1990
Homo sapiens, Mus musculus
Ghoda, L.Y.; Savarese, T.M.; Northup, C.H.; Parks, R.E.; Garofalo, J.; Katz, L.; Ellenbogen, B.B.; Bacchi, C.J.
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells
Mol. Biochem. Parasitol.
27
109-118
1988
Trypanosoma brucei brucei
Koszalka, G.W.; Krenitsky, T.A.
5'-Methyladenosine (MTA) phosphorylase from promastigotes of Leishmania donovani
Adv. Exp. Med. Biol.
195B
559-563
1986
Leishmania donovani
-
White, M.W.; Vandenbark, A.A.; Barney, C.L.; Ferro, A.J.
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation
Biochem. Pharmacol.
31
503-507
1982
Homo sapiens
Shugart, L.; Mahoney, L.; Chastain, B.
Kinetic studies of Drosophila melanogaster methylthioadenosine nucleoside phosphorylase
Int. J. Biochem.
13
559-564
1981
Drosophila melanogaster
Savarese, T.M.; Crabtree, G.W.; Parks, R.E.
5'-Methylthioadenosine phosphorylase. I. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells
Biochem. Pharmacol.
30
189-199
1981
Mus musculus
Shugart, L.; Tancer, M.; Moore, J.
Methylthioadenosine nucleoside phosphorylase activity in Drosophila melangoaster
Int. J. Biochem.
10
901-904
1979
Drosophila melanogaster
Zappia, V.; Carteni-Farina, M.; Romeo, G.; De Rosa, M.; Gambacorta, A.
Purification and properties of 5'-methyladenosine phosphorylase from Caldariella acidophila
Methods Enzymol.
94
355-361
1983
Caldariella acidophila
-
Zappia, V.; Oliva, A.; Cacciapuoti, G.; Galletti, P.; Mignucci, G.; Carteni-Farina, M.
Substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate
Biochem. J.
175
1043-1050
1978
Homo sapiens
Ferro, A.J.; Wrobel, N.C.; Nicolette, J.A.
5-Methylthioribose 1-phosphate: a product of partially purified, rat liver 5'-methylthioadenosine phosphorylase activity
Biochim. Biophys. Acta
570
65-73
1979
Rattus norvegicus
Della Ragione, F.; Carteni-Farina, M.; Gragnaniello, V.; Schettino, M.I.; Zappia, V.
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta
J. Biol. Chem.
261
12324-12329
1986
Homo sapiens
Della Ragione, F.; Oliva, A.; Gragnaniello, V.; Russo, G.L.; Palumbo, R.; Zappia, V.
Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase
J. Biol. Chem.
265
6241-6246
1990
Bos taurus
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; De Rosa, M.; Zappia, V.
Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds
J. Biol. Chem.
269
24762-24769
1994
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Fabianowska-Majewska, K.; Duley, J.; Fairbanks, L.; Simmonds, A.; Wasiak, T.
Substrate specificity of methylthioadenosine phosphorylase from human liver
Acta Biochim. Pol.
41
391-395
1994
Homo sapiens
Della Ragione, F.; Takabayashi, K.; Mastropietro, S.; Mercurio, C.; Oliva, A.; Russo, G.L.; Della Pietra, V.; Borriello, A.; Nobori, T.; et al.
Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification coding cDNA
Biochem. Biophys. Res. Commun.
223
514-519
1996
Homo sapiens
Nobori, T.; Takabayashi, K.; Tran, P.; Orvis, L.; Batova, A.; Yu, A.L.; Carson, D.A.
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers
Proc. Natl. Acad. Sci. USA
93
6203-6208
1996
Homo sapiens (Q13126), Homo sapiens
Yu, J.; Batova, A.; Shao, L.e.; Carrera, C.J.; Yu, A.L.
Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies
Clin. Cancer Res.
3
433-438
1997
Homo sapiens
Cacciapuoti, G.; Fusco, S.; Caiazzo, N.; Zappia, V.; Porcelli, M.
Heterologous expression of 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus: characterization of the recombinant protein and involvement of disulfide bonds in thermophilicity and thermostability
Protein Expr. Purif.
16
125-135
1999
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Bacchi, C.J.; Goldberg, B.; Rattendi, D.; Gorrell, T.E.; Spiess, A.J.; Sufrin, J.R.
Metabolic effects of a methylthioadenosine phosphorylase substrate analog on african trypanosomes
Biochem. Pharmacol.
57
89-96
1999
Trypanosoma brucei brucei
Appleby, T.C.; Erion, M.D.; Ealick, S.E.
The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis
Structure
7
629-641
1999
Homo sapiens
Slominska, E.M.; Kalsi, K.K.; Yacoub, M.H.; Smolenski, R.T.
The role of 5'-deoxy-5'-methyl thioadenosine phosphorylase in cardiac adenosine breakdown and adenine production
Adv. Exp. Med. Biol.
486
159-162
2000
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar, Sus scrofa
Tang, B.; Li, Y.N.; Kruger, W.D.
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth
Cancer Res.
60
5543-5547
2000
Homo sapiens
Cacciapuoti, G.; Servillo, L.; Moretti, M.A.; Porcelli, M.
Conformational changes and stabilization induced by phosphate binding to 5'-methylthioadenosine phosphorylase from the thermophilic archaeon Sulfolobus solfataricus
Extremophiles
5
295-302
2001
Saccharolobus solfataricus
Appleby, T.C.; Mathews, I.I.; Porcelli, M.; Cacciapuoti, G.; Ealick, S.E.
Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus
J. Biol. Chem.
276
39232-39242
2001
Saccharolobus solfataricus, Saccharolobus solfataricus (P50389)
Cacciapuoti, G.; Bertoldo, C.; Brio, A.; Zappia, V.; Porcelli, M.
Purification and characterization of 5'-methylthioadenosine phosphorylase from the hyperthermophilic archaeon Pyrococcus furiosus. Substrate specificity and primary structure analysis
Extremophiles
7
159-168
2003
Pyrococcus furiosus
Behrmann, I.; Wallner, S.; Komyod, W.; Heinrich, P.C.; Schuierer, M.; Buettner, R.; Bosserhoff, A.K.
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
Am. J. Pathol.
163
683-690
2003
Homo sapiens
Kadariya, Y.; Nishioka, J.; Nakatani, K.; Nakashima, K.; Nobori, T.
Deletion of dinucleotide repeat (DELTA14 allele) in the methylthioadenosine phosphorylase (MTAP) promoter and the allelotype of MTAP promoter in the Japanese population
Jpn. J. Cancer Res.
93
369-373
2002
Homo sapiens
Lee, J.E.; Settembre, E.C.; Cornell, K.A.; Riscoe, M.K.; Sufrin, J.R.; Ealick, S.E.; Howell, P.L.
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design
Biochemistry
43
5159-5169
2004
Homo sapiens (Q13126), Homo sapiens
Singh, V.; Shi, W.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Almo, S.C.; Schramm, V.L.
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Biochemistry
43
9-18
2004
Homo sapiens (Q13126), Homo sapiens
Kung, P.P.; Zehnder, L.R.; Meng, J.J.; Kupchinsky, S.W.; Skalitzky, D.J.; Johnson, M.C.; Maegley, K.A.; Ekker, A.; Kuhn, L.A.; Rose, P.W.; Bloom, L.A.
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates
Bioorg. Med. Chem. Lett.
15
2829-2833
2005
Homo sapiens
Cacciapuoti, G.; Moretti, M.A.; Forte, S.; Brio, A.; Camardella, L.; Zappia, V.; Porcelli, M.
Methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Mechanism of the reaction and assignment of disulfide bonds
Eur. J. Biochem.
271
4834-4844
2004
Pyrococcus furiosus
Cacciapuoti, G.; Forte, S.; Moretti, M.A.; Brio, A.; Zappia, V.; Porcelli, M.
A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus
FEBS J.
272
1886-1899
2005
Saccharolobus solfataricus
Subhi, A.L.; Diegelman, P.; Porter, C.W.; Tang, B.; Lu, Z.J.; Markham, G.D.; Kruger, W.D.
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites
J. Biol. Chem.
278
49868-49873
2003
Saccharomyces cerevisiae
Evans, G.B.; Furneaux, R.H.; Schramm, V.L.; Singh, V.; Tyler, P.C.
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase
J. Med. Chem.
47
3275-3281
2004
Homo sapiens
Wild, P.J.; Meyer, S.; Bataille, F.; Woenckhaus, M.; Ameres, M.; Vgt, T.; Landthaler, M.; Pauer, A.; Klinkhammer-Schalke, M.; Hofstaedter, F.; Bosserhoff, A.K.
Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors
Arch. Dermatol.
142
471-476
2006
Homo sapiens
Singh, V.; Schramm, V.L.
Transition-state structure of human 5-methylthioadenosine phosphorylase
J. Am. Chem. Soc.
128
14691-14696
2006
Homo sapiens
Evans, G.B.; Furneaux, R.H.; Lenz, D.H.; Painter, G.F.; Schramm, V.L.; Singh, V.; Tyler, P.C.
Second generation transition state analogue inhibitors of human 5-methylthioadenosine phosphorylase
J. Med. Chem.
48
4679-4689
2005
Homo sapiens
Karikari, C.A.; Mullendore, M.; Eshleman, J.R.; Argani, P.; Leoni, L.M.; Chattopadhyay, S.; Hidalgo, M.; Maitra, A.
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers
Mol. Cancer Ther.
4
1860-1866
2005
Homo sapiens
Parker, W.B.; Allan, P.W.; Ealick, S.E.; Sorscher, E.J.; Hassan, A.E.; Silamkoti, A.V.; Fowler, A.T.; Waud, W.R.; Secrist, J.A.
Design and evaluation of 5-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant
Nucleosides Nucleotides Nucleic Acids
24
387-392
2005
Homo sapiens
Cacciapuoti, G.; Porcelli, M.; Bertoldo, C.; Fusco, S.; De Rosa, M.; Zappia, V.
Extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Gene cloning and amino acid sequence determination.
Eur. J. Biochem.
239
632-637
1996
Saccharolobus solfataricus (P50389), Saccharolobus solfataricus
Siu, K.K.; Lee, J.E.; Sufrin, J.R.; Moffatt, B.A.; McMillan, M.; Cornell, K.A.; Isom, C.; Howell, P.L.
Molecular determinants of substrate specificity in plant 5-methylthioadenosine nucleosidases
J. Mol. Biol.
378
112-128
2008
Escherichia coli, Arabidopsis thaliana (Q7XA67), Arabidopsis thaliana (Q9T0I8), Arabidopsis thaliana
Williamson, R.E.; Darrow, K.N.; Michaud, S.; Jacobs, J.S.; Jones, M.C.; Eberl, D.F.; Maas, R.L.; Liberman, M.C.; Morton, C.C.
Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis
Am. J. Med. Genet. A
143A
1630-1639
2007
Homo sapiens (Q13126)
Alhebshi, H.M.; Pant, I.; Kaur, G.; Hashim, H.; Mabruk, M.J.
Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma
Asian Pac. J. Cancer Prev.
9
291-294
2008
Homo sapiens
Fernandez-Irigoyen, J.; Santamaria, M.; Sanchez-Quiles, V.; Latasa, M.U.; Santamaria, E.; Munoz, J.; Sanchez Del Pino, M.M.; Valero, M.L.; Prieto, J.; Avila, M.A.; Corrales, F.J.
Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications
Biochem. J.
411
457-465
2008
Homo sapiens, Mus musculus (Q9CQ65)
Miyazaki, S.; Nishioka, J.; Shiraishi, T.; Matsumine, A.; Uchida, A.; Nobori, T.
Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients
Int. J. Oncol.
31
1069-1076
2007
Homo sapiens
Basu, I.; Cordovano, G.; Das, I.; Belbin, T.J.; Guha, C.; Schramm, V.L.
A transition state analogue of 5-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers
J. Biol. Chem.
282
21477-21486
2007
Homo sapiens
Watanabe, F.; Takao, M.; Inoue, K.; Nishioka, J.; Nobori, T.; Shiraishi, T.; Kaneda, M.; Sakai, T.; Yada, I.; Shimpo, H.
Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma
Lung Cancer
63
39-44
2008
Homo sapiens
Luo, M.; Schramm, V.L.
Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-2H kinetic isotope effect
J. Am. Chem. Soc.
130
11617-11619
2008
Streptococcus pneumoniae
Gutierrez, J.A.; Crowder, T.; Rinaldo-Matthis, A.; Ho, M.C.; Almo, S.C.; Schramm, V.L.
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing
Nat. Chem. Biol.
5
251-257
2009
Escherichia coli, Vibrio harveyi, Escherichia coli O157:H7 EDL933
Oh, S.I.; Park, J.; Yoon, S.; Kim, Y.; Park, S.; Ryu, M.; Nam, M.J.; Ok, S.H.; Kim, J.K.; Shin, J.S.; Kim, K.N.
The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner
Plant Physiol.
148
1883-1896
2008
Arabidopsis thaliana (Q9T0I8)
Park, E.Y.; Choi, W.S.; Oh, S.I.; Kim, K.N.; Shin, J.S.; Song, H.K.
Biochemical and structural characterization of 5-methylthioadenosine nucleosidases from Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
381
619-624
2009
Arabidopsis thaliana (Q7XA67), Arabidopsis thaliana (Q9T0I8)
Kadariya, Y.; Yin, B.; Tang, B.; Shinton, S.A.; Quinlivan, E.P.; Hua, X.; Klein-Szanto, A.; Al-Saleem, T.I.; Bassing, C.H.; Hardy, R.R.; Kruger, W.D.
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma
Cancer Res.
69
5961-5969
2009
Mus musculus
Sommer, J.; Itani, D.M.; Homlar, K.C.; Keedy, V.L.; Halpern, J.L.; Holt, G.E.; Schwartz, H.S.; Coffin, C.M.; Kelley, M.J.; Cates, J.M.
Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
J. Pathol.
220
608-617
2010
Homo sapiens
Lubin, M.; Lubin, A.
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy
PLoS ONE
4
e5735
2009
Homo sapiens
Longshaw, A.I.; Adanitsch, F.; Gutierrez, J.A.; Evans, G.B.; Tyler, P.C.; Schramm, V.L.
Design and synthesis of potent sulfur-free transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase
J. Med. Chem.
53
6730-6746
2010
Escherichia coli
Zhang, Y.; Porcelli, M.; Cacciapuoti, G.; Ealick, S.E.
The crystal structure of 5-deoxy-5-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds
J. Mol. Biol.
357
252-262
2006
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus
Zhang, Y.; Zwart, P.H.; Ealick, S.E.
A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II
Acta Crystallogr. Sect. D
68
249-252
2012
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus P2 (Q97W94)
Guan, R.; Ho, M.C.; Brenowitz, M.; Tyler, P.C.; Evans, G.B.; Almo, S.C.; Schramm, V.L.
Entropy-driven binding of picomolar transition state analogue inhibitors to human 5-methylthioadenosine phosphorylase
Biochemistry
50
10408-10417
2011
Homo sapiens (Q13126), Homo sapiens
Cacciapuoti, G.; Marabotti, A.; Fuccio, F.; Porcelli, M.
Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5-deoxy-5-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus
Biochim. Biophys. Acta
1814
1358-1366
2011
Pyrococcus furiosus (Q8U4Q8), Pyrococcus furiosus
Cacciapuoti, G.; Fuccio, F.; Petraccone, L.; Del Vecchio, P.; Porcelli, M.
Role of disulfide bonds in conformational stability and folding of 5-deoxy-5-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus
Biochim. Biophys. Acta
1824
1136-1143
2012
Saccharolobus solfataricus
Buckoreelall, K.; Sun, Y.; Hobrath, J.V.; Wilson, L.; Parker, W.B.
Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis
Tuberculosis
92
139-147
2012
Mycobacterium tuberculosis (O06401), Mycobacterium tuberculosis
Porcelli, M.; Cacciapuoti, G.; Fusco, S.; Massa, R.; d'Ambrosio, G.; Bertoldo, C.; De Rosa, M.; Zappia, V.
Non-thermal effects of microwaves on proteins: thermophilic enzymes as model system
FEBS Lett.
402
102-106
1997
Saccharolobus solfataricus
Kang, X.; Zhao, Y.; Jiang, D.; Li, X.; Wang, X.; Wu, Y.; Chen, Z.; Zhang, X.C.
Crystal structure and biochemical studies of Brucella melitensis 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Biochem. Biophys. Res. Commun.
446
965-970
2014
Brucella melitensis (Q8YBL1)
Bagarolo, M.L.; Porcelli, M.; Martino, E.; Feller, G.; Cacciapuoti, G.
Multiple disulfide bridges modulate conformational stability and flexibility in hyperthermophilic archaeal purine nucleoside phosphorylase
Biochim. Biophys. Acta
1854
1458-1465
2015
Saccharolobus solfataricus (Q97W94), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97W94)
Guan, R.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.
Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase
Biochemistry
52
8313-8322
2013
Homo sapiens (Q13126), Homo sapiens
Lv, X.; Zhang, Y.; Rao, S.; Su, D.; Feng, D.; Wang, M.; Li, X.; Li, D.; Guo, H.; Zuo, X.; Xia, M.; Ouyang, H.; Ling, W.; Qiu, J.
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans
Gene
526
344-346
2013
Homo sapiens (Q13126), Homo sapiens
Vodnala, M.; Ranjbarian, F.; Pavlova, A.; de Koning, H.P.; Hofer, A.
Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine: implications for the pharmacology of adenosine antimetabolites
J. Biol. Chem.
291
11717-11726
2016
Trypanosoma brucei, Trypanosoma brucei TC221
Bistulfi, G.; Affronti, H.C.; Foster, B.A.; Karasik, E.; Gillard, B.; Morrison, C.; Mohler, J.; Phillips, J.G.; Smiraglia, D.J.
The essential role of methylthioadenosine phosphorylase in prostate cancer
Oncotarget
7
14380-14393
2016
Homo sapiens (Q13126), Homo sapiens
Becker, A.P.; Scapulatempo-Neto, C.; Menezes, W.P.; Clara, C.; Machado, H.R.; Oliveira, R.S.; Neder, L.; Reis, R.M.
Expression of methylthioadenosine phosphorylase (MTAP) in pilocytic astrocytomas
Pathobiology
82
84-89
2015
Homo sapiens
Bartasun, P.; Cieslinski, H.; Bujacz, A.; Wierzbicka-Wos, A.; Kur, J.
A study on the interaction of rhodamine B with methylthioadenosine phosphorylase protein sourced from an antarctic soil metagenomic library
PLoS ONE
8
e55697
2013
uncultured bacterium (C6KFA4)
Czech, B.; Dettmer, K.; Valletta, D.; Saugspier, M.; Koch, A.; Stevens, A.P.; Thasler, W.E.; Mueller, M.; Oefner, P.J.; Bosserhoff, A.K.; Hellerbrand, C.
Expression and function of methylthioadenosine phosphorylase in chronic liver disease
PLoS ONE
8
e80703
2013
Homo sapiens
Firestone, R.S.; Cameron, S.A.; Karp, J.M.; Arcus, V.L.; Schramm, V.L.
Heat capacity changes for transition-state analogue binding and catalysis with human 5'-methylthioadenosine phosphorylase
ACS Chem. Biol.
12
464-473
2017
Homo sapiens
Abid, H.; Harigua-Souiai, E.; Mejri, T.; Barhoumi, M.; Guizani, I.
Leishmania infantum 5'-methylthioadenosine phosphorylase presents relevant structural divergence to constitute a potential drug target
BMC Struct. Biol.
17
9-9
2017
Leishmania infantum, Leishmania infantum LV50
Torini, J.R.; Brandao-Neto, J.; DeMarco, R.; Pereira, H.D.
Crystal structure of Schistosoma mansoni adenosine phosphorylase/5'-methylthioadenosine phosphorylase and its importance on adenosine salvage pathway
PLoS Negl. Trop. Dis.
10
e0005178
2016
Schistosoma mansoni (I0B503), Schistosoma mansoni
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