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EC 1.2.1.50 Details
show Brenda entryEC number
1.2.1.50
Accepted name
long-chain acyl-protein thioester reductase
Reaction
a long-chain aldehyde + [protein]-L-cysteine + NADP+ = a [protein]-S-(long-chain fatty acyl)-L-cysteine + NADPH + H+;;
Other name(s)
luxC (gene name),
acyl-CoA reductase,
acyl coenzyme A reductase,
long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming),
long-chain-fatty-acyl-CoA reductase
Systematic name
long-chain-aldehyde:NADP+ oxidoreductase (protein thioester-forming)
CAS registry number
50936-56-6
Comment
Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA.
History
created 1986, modified 2016
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1 Oxidoreductases
1.1.1.70 created 1965, deleted 1978 1.1.1.74 created 1972, deleted 1976 1.1.1.89 created 1972, deleted 1976 1.1.1.109 created 1972, deleted 1976 1.1.1.139 created 1972, deleted 1978 1.1.1.155 created 1976, deleted 2004 1.1.1.171 created 1978, deleted 1984 1.1.1.180 created 1983, deleted 1984 1.1.1.182 created 1983, deleted 1990 1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004 1.1.1.242 created 1992, deleted 2001 1.1.1.253 created 1999, deleted 2003
1.1.2 With a cytochrome as acceptor 1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005 1.2.1.6 created 1961, deleted 1965 1.2.1.14 created 1961, deleted 1984 1.2.1.35 created 1972, deleted 1984 1.2.1.37 created 1972, deleted 1984 1.2.1.55 created 1990, deleted 2003 1.2.1.56 created 1990, deleted 2003
