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EC 1.2.1.71 Details
show Brenda entryEC number
1.2.1.71
Accepted name
succinylglutamate-semialdehyde dehydrogenase
Reaction
N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+
Other name(s)
succinylglutamic semialdehyde dehydrogenase,
N-succinylglutamate 5-semialdehyde dehydrogenase,
SGSD,
AruD,
AstD
Systematic name
N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase
Comment
This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].
History
created 2006
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1 Oxidoreductases
1.1.1.70 created 1965, deleted 1978 1.1.1.74 created 1972, deleted 1976 1.1.1.89 created 1972, deleted 1976 1.1.1.109 created 1972, deleted 1976 1.1.1.139 created 1972, deleted 1978 1.1.1.155 created 1976, deleted 2004 1.1.1.171 created 1978, deleted 1984 1.1.1.180 created 1983, deleted 1984 1.1.1.182 created 1983, deleted 1990 1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004 1.1.1.242 created 1992, deleted 2001 1.1.1.253 created 1999, deleted 2003
1.1.2 With a cytochrome as acceptor 1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005 1.2.1.6 created 1961, deleted 1965 1.2.1.14 created 1961, deleted 1984 1.2.1.35 created 1972, deleted 1984 1.2.1.37 created 1972, deleted 1984 1.2.1.55 created 1990, deleted 2003 1.2.1.56 created 1990, deleted 2003
