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EC 1.2.1.88 Details
show Brenda entryEC number
1.2.1.88
Accepted name
L-glutamate γ-semialdehyde dehydrogenase
Reaction
L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
Other name(s)
1-pyrroline-5-carboxylate dehydrogenase,
Δ1-pyrroline-5-carboxylate dehydrogenase,
1-pyrroline dehydrogenase,
pyrroline-5-carboxylate dehydrogenase,
pyrroline-5-carboxylic acid dehydrogenase,
L-pyrroline-5-carboxylate-NAD+ oxidoreductase,
1-pyrroline-5-carboxylate:NAD+ oxidoreductase,
Δ1-pyrroline-5-carboxylic acid dehydrogenase
Systematic name
L-glutamate γ-semialdehyde:NAD+ oxidoreductase
CAS registry number
9054-82-4
Comment
This enzyme catalyses the irreversible oxidation of glutamate-γ-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate γ-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].
History
created 1972 as EC 1.5.1.12, modified 2008, transferred 2013 to EC 1.2.1.88
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1 Oxidoreductases
1.1.1.70 created 1965, deleted 1978 1.1.1.74 created 1972, deleted 1976 1.1.1.89 created 1972, deleted 1976 1.1.1.109 created 1972, deleted 1976 1.1.1.139 created 1972, deleted 1978 1.1.1.155 created 1976, deleted 2004 1.1.1.171 created 1978, deleted 1984 1.1.1.180 created 1983, deleted 1984 1.1.1.182 created 1983, deleted 1990 1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004 1.1.1.242 created 1992, deleted 2001 1.1.1.253 created 1999, deleted 2003
1.1.2 With a cytochrome as acceptor 1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005 1.2.1.6 created 1961, deleted 1965 1.2.1.14 created 1961, deleted 1984 1.2.1.35 created 1972, deleted 1984 1.2.1.37 created 1972, deleted 1984 1.2.1.55 created 1990, deleted 2003 1.2.1.56 created 1990, deleted 2003
