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2.5.1.81: geranylfarnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about geranylfarnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.81

Reaction

geranylgeranyl diphosphate
+
isopentenyl diphosphate
=
(2E,6E,10E,14E)-geranylfarnesyl diphosphate
+
diphosphate

Synonyms

AtIDS1, AtIDS10, AtIDS6, AtIDS7, AtIDS9, C25 farnesylgeranyl diphosphate synthase, C25 FGPP synthase, farnesyl diphosphate synthase, farnesylgeranyl diphosphate synthase, FGPP synthase, Fgs, GFDP synthase, GFDP-forming enzyme, GFDPS, GFPS, IDS3, Lc-GFDPS, MM_0789

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.81 geranylfarnesyl diphosphate synthase

General Information

General Information on EC 2.5.1.81 - geranylfarnesyl diphosphate synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
phylogenetic analysis suggest that GFDPS probably evolved from plant geranylgeranyl diphosphate synthase under the influence of positive selection. Lc-GFDPS clusters in subcluster Ia, which is dominated by GGDPS sequences
malfunction
metabolism
-
biosynthesis of the C25 precursor geranylfarnesyl diphosphate to leucosceptroid sesterterpenoids is catalyzed by enzyme GFDPS that uses substrates geranylgeranyl diphosphate and Iisopentenyl diphosphate derived from the plastidial MEP pathway, overview
physiological function
-
the geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum, the C25 terpenoids might play a defensive role
additional information