Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.5.1.81: geranylfarnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about geranylfarnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.81

Reaction

geranylgeranyl diphosphate
+
isopentenyl diphosphate
=
(2E,6E,10E,14E)-geranylfarnesyl diphosphate
 +
diphosphate

Synonyms

AtIDS1, AtIDS10, AtIDS6, AtIDS7, AtIDS9, C25 farnesylgeranyl diphosphate synthase, C25 FGPP synthase, farnesyl diphosphate synthase, farnesylgeranyl diphosphate synthase, FGPP synthase, Fgs, GFDP synthase, GFDP-forming enzyme, GFDPS, GFPS, IDS3, Lc-GFDPS, MM_0789

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.81 geranylfarnesyl diphosphate synthase

Crystallization

Crystallization on EC 2.5.1.81 - geranylfarnesyl diphosphate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
model structure of mutant I112A, calculated using the model of wild-type GFPS as a template. In wild-type enzyme, the I112 on each subunit is located next to the I112 on the other at the dimer interface, to separate the two reaction cavities. In the mutant enzyme, the substitution of I112 by alanine results in the formation of a large tunnel between dimer subunits, enabling prenyl diphosphates to elongate through the newly-created path from one cavity to the other, thus yielding extremely lengthened prenyl diphosphates