2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

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For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file.

Reaction

Synonyms

2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.54 3-deoxy-7-phosphoheptulonate synthase

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Results	in table
18	Activating Compound
55180	AA Sequence
9	Application
1	CAS Registry Number
34	Cloned(Commentary)
22	Crystallization (Commentary)
2	Expression
24	General Information
17	General Stability
9	IC50 Value
247	Inhibitors
26	kcat/KM [mM/s]
31	Ki Value [mM]
146	KM Value [mM]
12	Localization
95	Metals/Ions
74	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
475	Organism
6	Pathway
224	PDB ID
62	pH Optimum
15	pH Range
2	pH Stability
1	pI Value
69	Protein Variants
56	Purification (Commentary)
31	Reaction
3	Reaction Type
146	Reference
4	Renatured (Commentary)
24	Source Tissue
56	Specific Activity [micromol/min/mg]
7	Storage Stability
194	Substrates and Products (Substrate)
53	Subunits
126	Synonyms
1	Systematic Name
41	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
60	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

24 entries

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

8 entries

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

2 entries

phosphoenolpyruvate + erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

2 entries

additional information

?

-

Escherichia coli

-

structure comparison between 3-deoxy-7-phosphoheptulonate synthase and 3-deoxy-D-manno-octulosonate 8-phosphate synthase, EC 4.1.2.16, reveal that they share a common ancestor and adopt the same catalytic strategy

637413

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Amycolatopsis mediterranei

-

first enzyme of the aromatic amino acid biosynthesis

639769

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Amycolatopsis mediterranei U-32

-

first enzyme of the aromatic amino acid biosynthesis

639769

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Amycolatopsis methanolica

-

key regulatory enzyme in L-Phe and L-Tyr biosynthesis

639778

-

639778

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Arabidopsis thaliana

-

first enzyme in the shikimic pathway leading to biosynthesis of aromatic amino acids

639798

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Arabidopsis thaliana

-

regulatory role of thioredoxin of photosystem I on the chloroplastic enzyme

639798

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Arabidopsis thaliana

-

DSH1 RNA levels increase in Arabidopsis leaves subjected either to physical wounding or to infiltration with pathogenic Pseudomonas syringae strains, DSH2 RNA levels are not increased by these treatments

639772

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Bacillus sp. (in: Bacteria)

-

first enzyme of aromatic amino acids, folic acid and phenazine 1-carboxylic acid biosynthesis pathways

639791

-

639791

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Bacillus sp. (in: Bacteria) B-6

-

first enzyme of aromatic amino acids, folic acid and phenazine 1-carboxylic acid biosynthesis pathways

639791

-

639791

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Brassica juncea

-

effect of external factors on regulation

639786

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Brassica juncea

-

one of the key regulator enzymes of the shikimic acid pathway

639786

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Cupriavidus necator

-

no repression by the aromatic amino acids

639745

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

-

no repression by the aromatic amino acids

639745

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Daucus carota

-

first enzyme of the aromatic amino acid biosynthesis

639758, 639765

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Escherichia coli

P0AB91

first enzyme in the shikimic pathway leading to biosynthesis of aromatic amino acids

639796

-

639796

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Escherichia coli

-

first enzyme of the aromatic amino acid biosynthesis

639746, 639767, 639771, 639774

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Escherichia coli

-

first enzyme of the aromatic amino acid biosynthesis

639783

-

639783

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Kitasatospora aureofaciens

-

first enzyme of the aromatic amino acid biosynthesis

639742

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Kitasatospora aureofaciens Tu24

-

first enzyme of the aromatic amino acid biosynthesis

639742

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Petroselinum crispum

-

the plastidic enzyme form is induced by fungal elicitor of Phytophthora megasperma, the cytosolic enzyme form is not induced

639773

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

first enzyme of the aromatic amino acid biosynthesis

639744

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Solanum tuberosum

-

-

639772

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Solanum tuberosum

-

enzyme is induced by N-[phosphomonomethyl]glycine

639755

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Solanum tuberosum

-

first enzyme of the aromatic amino acid biosynthesis

639755

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate

Xanthomonas campestris

-

-

639795

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Escherichia coli

P0AB91

-

738530

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Mycobacterium tuberculosis

O53512

-

738155

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Neisseria meningitidis

Q9K169

-

737813, 739438

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Neisseria meningitidis

-

-

739438

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Neisseria meningitidis

Q9K169

-

739599

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Neisseria meningitidis MC58

Q9K169

-

739599

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Oryza sativa

Q0D4J5

-

738708

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate

Thermotoga maritima

Q9WYH8

-

738228

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

Escherichia coli

-

-

710184

-

-

?

phosphoenolpyruvate + D-erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

Mycobacterium tuberculosis

O53512

-

701494

-

-

?

phosphoenolpyruvate + erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

Mycobacterium tuberculosis

O53512

-

703449

-

-

?

phosphoenolpyruvate + erythrose 4-phosphate + H2O

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

Mycobacterium tuberculosis H37Rv

O53512

-

703449

-

-

?