2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

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For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file.

Reaction

Synonyms

2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.54 3-deoxy-7-phosphoheptulonate synthase

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Results	in table
18	Activating Compound
55180	AA Sequence
9	Application
1	CAS Registry Number
34	Cloned(Commentary)
22	Crystallization (Commentary)
2	Expression
24	General Information
17	General Stability
9	IC50 Value
247	Inhibitors
26	kcat/KM [mM/s]
31	Ki Value [mM]
146	KM Value [mM]
12	Localization
95	Metals/Ions
74	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
475	Organism
6	Pathway
224	PDB ID
62	pH Optimum
15	pH Range
2	pH Stability
1	pI Value
69	Protein Variants
56	Purification (Commentary)
31	Reaction
3	Reaction Type
146	Reference
4	Renatured (Commentary)
24	Source Tissue
56	Specific Activity [micromol/min/mg]
7	Storage Stability
194	Substrates and Products (Substrate)
53	Subunits
126	Synonyms
1	Systematic Name
41	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
60	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.054

3-pyridine carboxyaldehyde

Mycobacterium tuberculosis

O53512

pH and temperature not specified in the publication

738155

0.021

alpha-tocopherol

Mycobacterium tuberculosis

O53512

pH and temperature not specified in the publication

738155

1

chorismate

Bacillus subtilis

-

IC50: 1 mM

674736

0.1

prephenate

Bacillus subtilis

-

IC50: 0.1 mM

674736

0.042

rutin

Mycobacterium tuberculosis

O53512

pH and temperature not specified in the publication

738155

0.0066

tetraammonium (((carboxymethyl)[(2S,3R,4S)-2,3,4-trihydroxy-5-(phosphonatooxy)pentyl]amino)methyl)phosphonate

Escherichia coli

-

IC50: 0.0066 mM

672596

0.0036

[(1E)-7-bromo-2-carboxyhept-1-en-1-yl]phosphonate

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

721804

0.0053

[2-carboxy-7-(phosphonatooxy)hept-1-en-1-yl]phosphonate

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

721804

0.154

[2-carboxy-7-(phosphonatooxy)hept-2-en-1-yl]phosphonate

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

721804