2.3.1.287: phthioceranic/hydroxyphthioceranic acid synthase

This is an abbreviated version!
For detailed information about phthioceranic/hydroxyphthioceranic acid synthase, go to the full flat file.

Reaction

7 (S)-methylmalonyl-CoA +

Synonyms

msl2, Pks2, polyketide synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.287 phthioceranic/hydroxyphthioceranic acid synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
5	AA Sequence
2	Expression
7	General Information
2	Natural Substrates/ Products (Substrates)
770	Organism
1	Pathway
2	Reaction
10	Reference
2	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name

Systematic Name

print visible entries

print all entries

Systematic Name on EC 2.3.1.287 - phthioceranic/hydroxyphthioceranic acid synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

(S)-methylmalonyl-CoA:palmitoyl-[(hydroxy)phthioceranic acid synthase] methylmalonyltransferase (phthioceranyl-[(hydroxy)phthioceranic acid synthase]-forming)

This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation [2].