1.14.18.2: CMP-N-acetylneuraminate monooxygenase
This is an abbreviated version!
For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.2
Reaction
Synonyms
CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah
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Reference on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lepers, A.; Shaw, L.; Schneckenburger, P.; Cacan, R.; Verbert, A.; Schauer, R.
A study on the regulation of N-glycoloylneuraminic acid biosynthesis and utilization in rat and mouse liver
Eur. J. Biochem.
193
715-723
1990
Mus musculus, Rattus norvegicus
Shaw, L.; Schauer, R.
The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid
Biol. Chem. Hoppe-Seyler
369
477-486
1988
Sus scrofa
Shaw, L.; Schauer, R.
Detection of CMP-N-acetylneuraminic acid hydroxylase activity in fractionated mouse liver
Biochem. J.
263
355-363
1989
Mus musculus
Kozutsumi, Y.; Kawano, T.; Yamakawa, T.; Suzuki, A.
Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol
J. Biochem.
108
704-706
1990
Mus musculus
Muchmore, E.A.; Milewski, M.; Varki, A.; Diaz, S.
Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool
J. Biol. Chem.
264
20216-20223
1989
Bos taurus, Mus musculus, Rattus norvegicus, Sus scrofa
Bergwerff, A.A.; Hulleman, S.H.D.; Kamerling, J.P.; Vliegenthart, J.F.G.; Shaw, L.; Reuter, G.; Schauer, R.
Nature and biosynthesis of sialic acids in the starfish Asterias rubens. Identification of sialo-oligomers and detection of S-adenosyl-L-methionine: N-acylneuraminate 8-O-methyltransferase and CMP-N-acetylneuraminate monooxygenase activities
Biochimie
74
25-37
1992
Asterias rubens
Schlenzka, W.; Shaw, L.; Kelm, S.; Schmidt, C.L.; Bill, E.; Trautwein, A.X.; Lottspeich, F.; Schauer, R.
CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulfur protein to be described in Eukarya
FEBS Lett.
385
197-200
1996
Sus scrofa
Shaw, L.; Schneckenburger, P.; Schlenzka, W.; Carlsen, J.; Christiansen, K.; Juergensen, D.; Schauer, R.
CMP-N-acetylneuraminic acid hydroxylase from mouse liver and pig submandibular glands. Interaction with membrane-bound and soluble cytochrome b5-dependent electron transport chains
Eur. J. Biochem.
219
1001-1011
1994
Bos taurus, Mus musculus, Sus scrofa
Martensen, I.; Schauer, R.; Shaw, L.
Cloning and expression of a membrane-bound CMP-N-acetylneuraminic acid hydroxylase from the starfish Asterias rubens
Eur. J. Biochem.
268
5157-5166
2001
Asterias rubens
Kawano, T.; Kozutsumi, Y.; Kawasaki, T.; Suzuki, A.
Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N-acetylneuraminic acid hydroxylation system
J. Biol. Chem.
269
9024-9029
1994
Mus musculus
Kawano, T.; Koyama, S.; Takematsu, H.; Kozutsumi, Y.; Kawasaki, H.; Kawashima, S.; Kawasaki, T.; Suzuki, A.
Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid
J. Biol. Chem.
270
16458-16463
1995
Mus musculus
Chou, H.H.; Hayakawa, T.; Diaz, S.; Krings, M.; Indriati, E.; Leakey, M.; Paabo, S.; Satta, Y.; Takahata, N.; Varki, A.
Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
Proc. Natl. Acad. Sci. USA
99
11736-11741
2002
no activity in Homo sapiens
Irie, A.; Suzuki, A.
CMP-N-acetylneuraminic acid hydroxylase is exclusively inactive in humans
Biochem. Biophys. Res. Commun.
248
330-333
1998
Mus musculus, no activity in Homo sapiens
Schlenzka, W.; Shaw, L.; Schauer, R.
Catalytic properties of the CMP-N-acetylneuraminic acid hydroxylase from the starfish Asterias rubens: comparison with the mammalian enzyme
Biochim. Biophys. Acta
1161
131-138
1993
Asterias rubens
Takematsu, H.; Kawano, T.; Koyama, S.; Kozutsumi, Y.; Suzuki, A.; Kawasaki, T.
Reaction mechanism underlying CMP-N-acetylneuraminic acid hydroxylation in mouse liver: formation of a ternary complex of cytochrome b5, CMP-N-acetylneuraminic acid, and a hydroxylation enzyme
J. Biochem.
115
381-386
1994
Mus musculus
Schneckenburger, P.; Shaw, L.; Schauer, R.
Purification, characterization and reconstitution of CMP-N-acetylneuraminate hydroxylase from mouse liver
Glycoconjugate J.
11
194-203
1994
Mus musculus
Koyama, S.; Yamaji, T.; Takematsu, H.; Kawano, T.; Kozutsumi, Y.; Suzuki, A.; Kawasaki, T.
A naturally occurring 46-amino acid deletion of cytidine monophospho-N-acetylneuraminic acid hydroxylase leads to a change in the intracellular distribution of the protein
Glycoconjugate J.
13
353-358
1996
Mus musculus
Malykh, Y.N.; Shaw, L.; Schauer, R.
The role of CMP-N-acetylneuraminic acid hydroxylase in determining the level of N-glycolylneuraminic acid in porcine tissues
Glycoconjugate J.
15
885-893
1998
Sus scrofa
Malykh, Y.N.; Krisch, B.; Shaw, L.; Warner, T.G.; Sinicrop, D.; Smith, R.; Chang, J.; Schauer, R.
Distribution and localization of CMP-N-acetylneuraminic acid hydroxylase and N-glycolylneuraminic acid-containing glycoconjugates in porcine lymph node and peripheral blood lymphocytes
Eur. J. Cell Biol.
80
48-58
2001
Sus scrofa
Gollub, M.; Schauer, R.; Shaw, L.
Cytidine monophosphate-N-acetylneuraminate hydroxylase in the starfish Asterias rubens and other echinoderms
Comp. Biochem. Physiol. B
120
605-615
1998
Asterias rubens, Ctenodiscus crispatus, Muelleria sp., Strongylocentrotus pallidus
Gollub, M.; Shaw, L.
Isolation and characterization of cytidine-5'-monophosphate-N-acetylneuraminate hydroxylase from the starfish Asterias rubens
Comp. Biochem. Physiol. B
134
89-101
2003
Asterias rubens
Schlenzka, W.; Shaw, L.; Schneckenburger, P.; Schauer, R.
Purification and characterization of CMP-N-acetylneuraminic acid hydroxylase from pig submandibular glands
Glycobiology
4
675-683
1994
Sus scrofa
Shaw, L.; Schneckenburger, P.; Carlsen, J.; Christiansen, K.; Schauer, R.
Mouse liver cytidine-5-monophosphate-N-acetylneuraminic acid hydroxylase. Catalytic function and regulation
Eur. J. Biochem.
206
269-277
1992
Mus musculus
Malykh, Y.N.; King, T.P.; Logan, E.; Kelly, D.; Schauer, R.; Shaw, L.
Regulation of N-glycolylneuraminic acid biosynthesis in developing pig small intestine
Biochem. J.
22
2-29
2002
Sus scrofa
-
Chenu, S.; Gregoire, A.; Malykh, Y.; Visvikis, A.; Monaco, L.; Shaw, L.; Schauer, R.; Marc, A.; Goergen, J.L.
Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy
Biochim. Biophys. Acta
1622
133-144
2003
Cricetulus griseus
Malykh, Y.N.; Schauer, R.; Shaw, L.
N-Glycolylneuraminic acid in human tumours
Biochimie
83
623-634
2001
Homo sapiens
Hayakawa, T.; Aki, I.; Varki, A.; Satta, Y.; Takahata, N.
Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution
Genetics
172
1139-1146
2006
no activity in Homo sapiens
Bighignoli, B.; Niini, T.; Grahn, R.A.; Pedersen, N.C.; Millon, L.V.; Polli, M.; Longeri, M.; Lyons, L.A.
Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group
BMC Genet.
8
27
2007
Felis catus
Schauer, R.; Srinivasan, G.V.; Coddeville, B.; Zanetta, J.P.; Guerardel, Y.
Low incidence of N-glycolylneuraminic acid in birds and reptiles and its absence in the platypus
Carbohydr. Res.
344
1494-1500
2009
no activity in Gallus gallus, no activity in Ornithorhynchus anatinus, no activity in Taeniopygia guttata
Nystedt, J.; Anderson, H.; Hirvonen, T.; Impola, U.; Jaatinen, T.; Heiskanen, A.; Blomquist, M.; Satomaa, T.; Natunen, J.; Saarinen, J.; Lehenkari, P.; Valmu, L.; Laine, J.
Human CMP-N-acetylneuraminic acid hydroxylase (CMAH) is a novel stem cell marker linked to stem cell-specific mechanisms
Stem Cells
28
258-267
2010
Homo sapiens (C1K3L2), Homo sapiens
Song, K.H.; Kang, Y.J.; Jin, U.H.; Park, Y.I.; Kim, S.M.; Seong, H.H.; Hwang, S.; Yang, B.S.; Im, G.S.; Min, K.S.; Kim, J.H.; Chang, Y.C.; Kim, N.H.; Lee, Y.C.; Kim, C.H.
Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation
Biochem. J.
427
179-188
2010
Sus scrofa (A8WAC5), Sus scrofa
Kavaler, S.; Morinaga, H.; Jih, A.; Fan, W.; Hedlund, M.; Varki, A.; Kim, J.J.
Pancreatic {beta}-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency
FASEB J.
25
1887-1893
2011
Mus musculus
Tahara, H.; Ide, K.; Basnet, N.B.; Tanaka, Y.; Matsuda, H.; Takematsu, H.; Kozutsumi, Y.; Ohdan, H.
Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice
J. Immunol.
184
3269-3275
2010
Mus musculus
Bergfeld, A.; Pearce, O.; Diaz, S.; Pham, T.; Varki, A.
Metabolism of vertebrate amino sugars with N-glycolyl groups: Elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid
J. Biol. Chem.
287
28865-28881
2012
Mus musculus
Ikeda, K.; Yamamoto, A.; Nanjo, A.; Inuinaka, C.; Takama, Y.; Ueno, T.; Fukuzawa, M.; Nakano, K.; Matsunari, H.; Nagashima, H.; Miyagawa, S.
A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells
Transplant. Proc.
44
1136-1138
2012
Sus scrofa
Takahashi, T.; Kawagishi, S.; Funahashi, H.; Hayashi, N.; Suzuki, T.
Production and purification of secretory simian cytidine monophosphate-N-acetylneuraminic acid hydroxylase using baculovirus-protein expression system
Biol. Pharm. Bull.
38
1220-1226
2015
Chlorocebus aethiops, no activity in Homo sapiens
Gao, H.; Zhao, C.; Xiang, X.; Li, Y.; Zhao, Y.; Li, Z.; Pan, D.; Dai, Y.; Hara, H.; Cooper, D.K.; Cai, Z.; Mou, L.
Production of alpha1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning
J. Reprod. Dev.
63
17-26
2017
Sus scrofa
Gandolfi, B.; Grahn, R.A.; Gustafson, N.A.; Proverbio, D.; Spada, E.; Adhikari, B.; Cheng, J.; Andrews, G.; Lyons, L.A.; Helps, C.R.
A novel variant in CMAH is associated with blood type AB in Ragdoll cats
PLoS ONE
11
e0154973
2016
Felis catus
Omi, T.; Nakazawa, S.; Udagawa, C.; Tada, N.; Ochiai, K.; Chong, Y.H.; Kato, Y.; Mitsui, H.; Gin, A.; Oda, H.; Azakami, D.; Tamura, K.; Sako, T.; Inagaki, T.; Sakamoto, A.; Tsutsui, T.; Bonkobara, M.; Tsuchida, S.; Ikemoto, S.
Molecular characterization of the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene associated with the feline AB blood group system
PLoS ONE
11
e0165000
2016
Felis catus (A6Y8N2), Felis catus
Sakai, R.; Esaki, Y.; Hasuwa, H.; Ikawa, M.; Lo, P.; Matsuura, R.; Nakahata, K.; Zenitani, M.; Asada, M.; Maeda, A.; Eguchi, H.; Okuyama, H.; Miyagawa, S.
Knockout of cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylase from porcine endothelial cells by a CRISPR system
Transplant. Proc.
48
1320-1322
2016
Sus scrofa (O19074), Sus scrofa
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