1.14.18.2: CMP-N-acetylneuraminate monooxygenase
This is an abbreviated version!
For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah
ECTree
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Engineering
Engineering on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase
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additional information
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mutations in type B cats likely disrupt the gene function of CMAH, leading to a predominance of NeuAc in blood types, genotyping, overview
additional information
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naturally occuring truncated protein, lacking 46 amino acids in the middle of the normal full-length protein, causes a change in intracellular distribution of the enzyme from cytosol to endoplasmic reticulum and a loss in activity
additional information
knockout of the expression of Hanganutziu-Deicher (H-D) antigens through the use of a CRISPR (clustered regulatory interspaced short palindromic repeat)/Cas9 system for pig cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH). Pig endothelial cells (PECs) from an alpha-Gal knockout pig are used to examine the changes in the expression of the H-D antigen by the knockout of the CMAH genome by the pX330-gS01. Method, overview
additional information
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knockout of the expression of Hanganutziu-Deicher (H-D) antigens through the use of a CRISPR (clustered regulatory interspaced short palindromic repeat)/Cas9 system for pig cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH). Pig endothelial cells (PECs) from an alpha-Gal knockout pig are used to examine the changes in the expression of the H-D antigen by the knockout of the CMAH genome by the pX330-gS01. Method, overview
additional information
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production of alpha1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and cloning in porcine fetal fibroblast cells. Generation of bi-allelic GGTA1 and CMAH double-knockout cells, GGTA1/CMAH double-knockout (DKO) cells are cloned to produce piglets. Compared to cells from GGTA1-knockout pigs, human antibody binding and antibody-mediated complement-dependent cytotoxicity are significantly reduced in cells from GGTA1/CMAH DKO pigs, demonstrating that the pigs might exhibit reduced humoral rejection in xenotransplantation