1.14.14.114: amorpha-4,11-diene 12-monooxygenase
This is an abbreviated version!
For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.114
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1.14.14.114
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annua
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artemisia
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malaria
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artemisinic
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trichomes
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sesquiterpene
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dihydroartemisinic
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lactone
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glandular
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anti-malarial
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trichome-specific
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farnesyl
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endoperoxide
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sesquiterpenoids
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artemisinin-based
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one-hybrid
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arteannuin
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amorphadiene
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asteraceae
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synthesis
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t-shaped
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jasmonate-responsive
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12-hydroxylase
- 1.14.14.114
- annua
- artemisia
-
malaria
-
artemisinic
- trichomes
-
sesquiterpene
-
dihydroartemisinic
- lactone
-
glandular
-
anti-malarial
-
trichome-specific
-
farnesyl
-
endoperoxide
- sesquiterpenoids
-
artemisinin-based
-
one-hybrid
-
arteannuin
-
amorphadiene
- asteraceae
- synthesis
-
t-shaped
-
jasmonate-responsive
-
12-hydroxylase
Reaction
+ 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Synonyms
ALDH1, amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1, EC 1.14.13.158
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase
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REACTION DIAGRAM
2-nonenal + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
amorpha-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
artemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
artemisinic aldehyde + [reduced NADPH-hemoprotein reductase] + O2
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
dihydroartemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2
dihydroartemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
dihydroartemisinic aldehyde + [reduced NADPH-hemoprotein reductase] + O2
dihydroartemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
octanal + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
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-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process
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-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process
-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction via artemsinic alcohol and artemsinic aldehyde, multistep process
-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reaction, multistep process
-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
overall reactionvia artemsinic alcohol and artemsinic aldehyde, multistep process
-
-
?
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
-
-
-
?
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
amorpha-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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-
-
?
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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-
-
-
?
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
?
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
-
?
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
artemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
artemisinic aldehyde + [reduced NADPH-hemoprotein reductase] + O2
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
?
dihydroartemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
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-
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?
dihydroartemisinic alcohol + [reduced NADPH-hemoprotein reductase] + O2
dihydroartemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
about 50% of the rate with artemisinic alcohol
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-
?
additional information
?
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no substrate: dihydroartemisinic aldehyde
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?
additional information
?
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no substrates: limonene, alpha-pinene, beta-pinene and pinocarveol, and the sesquiterpenes ()-alloisolongifolene, caryophyllene, ()-alpha-gurjunene, (+)-gamma-gurjunene, (+)-ledene,(+)-beta-selinene and (+)-valencene
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-
?
additional information
?
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no substrates: limonene, alpha-pinene, beta-pinene and pinocarveol, and the sesquiterpenes ()-alloisolongifolene, caryophyllene, ()-alpha-gurjunene, (+)-gamma-gurjunene, (+)-ledene,(+)-beta-selinene and (+)-valencene
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-
?
additional information
?
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no substrates: Sinapaldehyde, 2-phenylpropanal
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-
?
additional information
?
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no substrates: Sinapaldehyde, 2-phenylpropanal
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?
additional information
?
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conversion of dihydroartemsinic aldehyde to artemisinate is nonenzymatic in trichomes by nonenzymatic autoxidation of dihydroartemsinic aldehyde to dihydroartemsinic acid tertiary hydroperoxide and subsequent nonenzymatic rearrangement to artemisinin
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-
?
additional information
?
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conversion of dihydroartemsinic aldehyde to artemisinate is nonenzymatic in trichomes by nonenzymatic autoxidation of dihydroartemsinic aldehyde to dihydroartemsinic acid tertiary hydroperoxide and subsequent nonenzymatic rearrangement to artemisinin
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-
?