1.14.14.114: amorpha-4,11-diene 12-monooxygenase
This is an abbreviated version!
For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.114
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1.14.14.114
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annua
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artemisia
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malaria
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artemisinic
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trichomes
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sesquiterpene
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dihydroartemisinic
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lactone
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glandular
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anti-malarial
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trichome-specific
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farnesyl
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endoperoxide
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sesquiterpenoids
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artemisinin-based
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one-hybrid
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arteannuin
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amorphadiene
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asteraceae
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synthesis
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t-shaped
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jasmonate-responsive
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12-hydroxylase
- 1.14.14.114
- annua
- artemisia
-
malaria
-
artemisinic
- trichomes
-
sesquiterpene
-
dihydroartemisinic
- lactone
-
glandular
-
anti-malarial
-
trichome-specific
-
farnesyl
-
endoperoxide
- sesquiterpenoids
-
artemisinin-based
-
one-hybrid
-
arteannuin
-
amorphadiene
- asteraceae
- synthesis
-
t-shaped
-
jasmonate-responsive
-
12-hydroxylase
Reaction
+ 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Synonyms
ALDH1, amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1, EC 1.14.13.158
ECTree
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Source Tissue
Source Tissue on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase
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expression of farnesyl diphosphate synthase takes place in apical and sub-apical cells as well as in mesophyl cells while the three enzymes involved in artemisinin biosynthesis, i.e. amorpha-4,11-diene synthase, amorpha-4,11-diene hydroxylase, a cytochrome P450 monooxygenase, and artemisinic aldehyde DELTA11(13) reductase are expressed only in the apical cells
the production of artemisinin occurs in specialized 10-cell biseriate glandular trichomes present on the leaves, stems, and inflorescences of Artemisia annua
artemisinin production in Artemisia annua is localized in glandular trichomes on the surface of leaves, shoots and flowers
of stems, old and young leaves, and flower buds gathered 5-20 d after budding