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EC 1.4.1.21 Details
show Brenda entryEC number
1.4.1.21
Accepted name
aspartate dehydrogenase
Reaction
L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ (overall reaction);;(1a) L-aspartate + NAD(P)+ = 2-iminosuccinate + NAD(P)H + H+;;(1b) 2-iminosuccinate + H2O = oxaloacetate + NH3 (spontaneous)
Other name(s)
AspDH,
NAD-dependent aspartate dehydrogenase,
NADH2-dependent aspartate dehydrogenase,
NADP+-dependent aspartate dehydrogenase,
nadX (gene name),
L-aspartate:NAD(P)+ oxidoreductase (deaminating)
Systematic name
L-aspartate:NAD(P)+ oxidoreductase (2-iminosuccinate-forming)
CAS registry number
37278-97-0
Comment
The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+.
History
created 2005, modified 2022
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.1.6 created 1961, deleted 1982 1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000 1.14.99.6 created 1972, modified 2000, deleted 2000 1.14.99.8 created 1972, deleted 1984 1.14.99.13 created 1972, deleted 1984 1.14.99.16 created 1972, deleted 2002 1.14.99.17 created 1972, deleted 1976 1.14.99.18 created 1976, modified 1999, deleted 2003 1.14.99.25 created 1986, deleted 2000
