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EC 1.4.1.18 Details
show Brenda entryEC number
1.4.1.18
Accepted name
lysine 6-dehydrogenase
Reaction
L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction);;(1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3;;(1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)
Other name(s)
L-lysine ε-dehydrogenase,
L-lysine 6-dehydrogenase,
LysDH
Systematic name
L-lysine:NAD+ 6-oxidoreductase (deaminating)
CAS registry number
89400-30-6
Comment
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].
History
created 1989, modified 2006, modified 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.1.6 created 1961, deleted 1982 1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000 1.14.99.6 created 1972, modified 2000, deleted 2000 1.14.99.8 created 1972, deleted 1984 1.14.99.13 created 1972, deleted 1984 1.14.99.16 created 1972, deleted 2002 1.14.99.17 created 1972, deleted 1976 1.14.99.18 created 1976, modified 1999, deleted 2003 1.14.99.25 created 1986, deleted 2000
