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EC 1.4.99.6 Details
show Brenda entryEC number
1.4.99.6
Accepted name
D-arginine dehydrogenase
Reaction
D-arginine + acceptor + H2O = 5-guanidino-2-oxopentanoate + NH3 + reduced acceptor (overall reaction);;(1a) D-arginine + acceptor = iminoarginine + reduced acceptor;;(1b) iminoarginine + H2O = 5-guanidino-2-oxopentanoate + NH3 (spontaneous)
Other name(s)
D-amino-acid:(acceptor) oxidoreductase (deaminating),
D-amino-acid dehydrogenase,
D-amino-acid:acceptor oxidoreductase (deaminating)
Systematic name
D-arginine:acceptor oxidoreductase (deaminating)
CAS registry number
37205-44-0
Comment
Contains a non-covalent FAD cofactor. The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.1.25, L-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine. The enzyme has a broad substrate range and can act on most D-amino acids with the exception of D-glutamate and D-aspartate. However, activity is maximal with D-arginine and D-lysine. Not active on glycine.
History
created 1972 as EC 1.4.99.1, transferred 2015 to EC 1.4.99.6, modified 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000 1.14.99.6 created 1972, modified 2000, deleted 2000 1.14.99.8 created 1972, deleted 1984 1.14.99.13 created 1972, deleted 1984 1.14.99.16 created 1972, deleted 2002 1.14.99.17 created 1972, deleted 1976 1.14.99.18 created 1976, modified 1999, deleted 2003 1.14.99.25 created 1986, deleted 2000
