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EC 1.14.16.7 Details
show Brenda entryEC number
1.14.16.7
Accepted name
phenylalanine 3-monooxygenase
Reaction
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = 3-hydroxy-L-phenylalanine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other name(s)
PacX,
phenylalanine 3-hydroxylase
Systematic name
L-phenylalanine,tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating)
Comment
The enzyme, characterized from the bacterium Streptomyces coeruleorubidus, forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.
History
created 2014, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.1.6 created 1961, deleted 1982
