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EC 1.14.16.6 Details
show Brenda entryEC number
1.14.16.6
Accepted name
mandelate 4-monooxygenase
Reaction
(S)-2-hydroxy-2-phenylacetate + a 5,6,7,8-tetrahydropteridine + O2 = (S)-4-hydroxymandelate + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other name(s)
L-mandelate 4-hydroxylase,
mandelic acid 4-hydroxylase
Systematic name
(S)-2-hydroxy-2-phenylacetate,tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating)
CAS registry number
39459-82-0
Comment
Requires Fe2+. The enzyme has been characterized from the bacterium Pseudomonas putida. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.
History
created 1984, modified 2020
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.1.6 created 1961, deleted 1982
