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EC 1.4.3.13 Details

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EC number

1.4.3.13

Accepted name

protein-lysine 6-oxidase

Reaction

[protein]-L-lysine + O₂ + H₂O = [protein]-(S)-2-amino-6-oxohexanoate + NH₃ + H₂O₂

Other name(s)

lysyl oxidase

Systematic name

protein-L-lysine:oxygen 6-oxidoreductase (deaminating)

CAS registry number

99676-44-5

Comment

Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].

History

created 1980, modified 1983

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

1.4.3.2 L-amino-acid oxidase

1.4.3.3 D-amino-acid oxidase

1.4.3.4 monoamine oxidase

1.4.3.5 pyridoxal 5′-phosphate synthase

1.4.3.6 amine oxidase (copper-containing)

1.4.3.7 D-glutamate oxidase

1.4.3.8 ethanolamine oxidase

1.4.3.9 created 1972, deleted 1984

1.4.3.10 putrescine oxidase

1.4.3.11 L-glutamate oxidase

1.4.3.12 cyclohexylamine oxidase

1.4.3.13 protein-lysine 6-oxidase

1.4.3.14 L-lysine oxidase

1.4.3.15 D-glutamate(D-aspartate) oxidase

1.4.3.16 L-aspartate oxidase

1.4.3.17 created 2000, deleted 2003

1.4.3.18 proposed 2000

1.4.3.19 glycine oxidase

1.4.3.20 L-lysine 6-oxidase

1.4.3.21 primary-amine oxidase

1.4.3.22 diamine oxidase

1.4.3.23 7-chloro-L-tryptophan oxidase

1.4.3.24 pseudooxynicotine oxidase

1.4.3.25 L-arginine oxidase

1.4.3.26 pre-mycofactocin synthase

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.1. undefined

1.13.11 With incorporation of two atoms of oxygen

1.13.11.1 catechol 1,2-dioxygenase

1.13.11.2 catechol 2,3-dioxygenase

1.13.11.3 protocatechuate 3,4-dioxygenase

1.13.11.4 gentisate 1,2-dioxygenase

1.13.11.5 homogentisate 1,2-dioxygenase

1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase

1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980

1.13.11.8 protocatechuate 4,5-dioxygenase

1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase

1.13.11.10 7,8-dihydroxykynurenate 8,8a-dioxygenase

1.13.11.11 tryptophan 2,3-dioxygenase

1.13.11.12 linoleate 13S-lipoxygenase

1.13.11.13 ascorbate 2,3-dioxygenase

1.13.11.14 2,3-dihydroxybenzoate 3,4-dioxygenase

1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase

1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase

1.13.11.17 indole 2,3-dioxygenase

1.13.11.18 persulfide dioxygenase

1.13.11.19 cysteamine dioxygenase

1.13.11.20 cysteine dioxygenase

1.13.11.21 created 1972, deleted 2001

1.13.11.22 caffeate 3,4-dioxygenase

1.13.11.23 2,3-dihydroxyindole 2,3-dioxygenase

1.13.11.24 quercetin 2,3-dioxygenase

1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

1.13.11.26 peptide-tryptophan 2,3-dioxygenase

1.13.11.27 4-hydroxyphenylpyruvate dioxygenase

1.13.11.28 2,3-dihydroxybenzoate 2,3-dioxygenase

1.13.11.29 stizolobate synthase

1.13.11.30 stizolobinate synthase

1.13.11.31 arachidonate 12-lipoxygenase

1.13.11.32 2-nitropropane dioxygenase

1.13.11.33 arachidonate 15-lipoxygenase

1.13.11.34 arachidonate 5-lipoxygenase

1.13.11.35 pyrogallol 1,2-oxygenase

1.13.11.36 chloridazon-catechol dioxygenase

1.13.11.37 hydroxyquinol 1,2-dioxygenase

1.13.11.38 1-hydroxy-2-naphthoate 1,2-dioxygenase

1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase

1.13.11.40 arachidonate 8-lipoxygenase

1.13.11.41 2,4′-dihydroxyacetophenone dioxygenase

1.13.11.42 indoleamine-pyrrole 2,3-dioxygenase

1.13.11.43 lignostilbene αβ-dioxygenase

1.13.11.44 linoleate diol synthase

1.13.11.45 linoleate 11-lipoxygenase

1.13.11.46 4-hydroxymandelate synthase

1.13.11.47 3-hydroxy-4-oxoquinoline 2,4-dioxygenase

1.13.11.48 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

1.13.11.49 chlorite O₂-lyase

1.13.11.50 acetylacetone-cleaving enzyme

1.13.11.51 9-cis-epoxycarotenoid dioxygenase

1.13.11.52 indoleamine 2,3-dioxygenase

1.13.11.53 acireductone dioxygenase (Ni²⁺-requiring)

1.13.11.54 acireductone dioxygenase [iron(II)-requiring]

1.13.11.55 sulfur oxygenase/reductase

1.13.11.56 1,2-dihydroxynaphthalene dioxygenase

1.13.11.57 gallate dioxygenase

1.13.11.58 linoleate 9S-lipoxygenase

1.13.11.59 torulene dioxygenase

1.13.11.60 linoleate 8R-lipoxygenase

1.13.11.61 linolenate 9R-lipoxygenase

1.13.11.62 linoleate 10R-lipoxygenase

1.13.11.63 β-carotene 15,15′-dioxygenase

1.13.11.64 5-nitrosalicylate dioxygenase

1.13.11.65 carotenoid isomerooxygenase

1.13.11.66 hydroquinone 1,2-dioxygenase

1.13.11.67 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase

1.13.11.68 9-cis-β-carotene 9′,10′-cleaving dioxygenase

1.13.11.69 carlactone synthase

1.13.11.70 all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase

1.13.11.71 carotenoid-9′,10′-cleaving dioxygenase

1.13.11.72 2-hydroxyethylphosphonate dioxygenase

1.13.11.73 methylphosphonate synthase

1.13.11.74 2-aminophenol 1,6-dioxygenase

1.13.11.75 all-trans-8′-apo-β-carotenal 15,15′-oxygenase

1.13.11.76 2-amino-5-chlorophenol 1,6-dioxygenase

1.13.11.77 oleate 10S-lipoxygenase

1.13.11.78 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)

1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase

1.13.11.80 (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

1.13.11.81 7,8-dihydroneopterin oxygenase

1.13.11.82 8′-apo-carotenoid 13,14-cleaving dioxygenase

1.13.11.83 4-hydroxy-3-prenylphenylpyruvate oxygenase

1.13.11.84 crocetin dialdehyde synthase

1.13.11.85 exo-cleaving rubber dioxygenase

1.13.11.86 5-aminosalicylate 1,2-dioxygenase

1.13.11.87 endo-cleaving rubber dioxygenase

1.13.11.88 isoeugenol monooxygenase

1.13.11.89 (hydroxymethyl)phosphonate dioxygenase

1.13.11.90 [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)

1.13.11.91 3-mercaptopropionate dioxygenase

1.13.11.92 fatty acid α-dioxygenase

1.13.11.93 2-oxoadipate dioxygenase/decarboxylase

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.99 Miscellaneous

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)