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EC 1.4.3.5 Details
show Brenda entryEC number
1.4.3.5
Accepted name
pyridoxal 5′-phosphate synthase
Reaction
(1) pyridoxamine 5′-phosphate + H2O + O2 = pyridoxal 5′-phosphate + NH3 + H2O2;;(2) pyridoxine 5′-phosphate + O2 = pyridoxal 5′-phosphate + H2O2
Other name(s)
pyridoxamine 5′-phosphate oxidase,
pyridoxamine phosphate oxidase,
pyridoxine (pyridoxamine)phosphate oxidase,
pyridoxine (pyridoxamine) 5′-phosphate oxidase,
pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating),
PMP oxidase,
pyridoxol-5′-phosphate:oxygen oxidoreductase (deaminating) (incorrect),
pyridoxamine-phosphate oxidase,
PdxH
Systematic name
pyridoxamine-5′-phosphate:oxygen oxidoreductase (deaminating)
CAS registry number
9029-21-4
Comment
A flavoprotein (FMN). In Escherichia coli, the coenzyme pyridoxal 5′-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5′-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5′-phosphate as substrate). N4′-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine.
History
created 1961, modified 2006
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000 1.13.11.21 created 1972, deleted 2001
