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EC 1.3.1.1 Details
show Brenda entryEC number
1.3.1.1
Accepted name
dihydropyrimidine dehydrogenase (NAD+)
Reaction
(1) 5,6-dihydrouracil + NAD+ = uracil + NADH + H+;;(2) 5,6-dihydrothymine + NAD+ = thymine + NADH + H+
Other name(s)
dihydropyrimidine dehydrogenase,
dihydrothymine dehydrogenase,
pyrimidine reductase,
thymine reductase,
uracil reductase,
dihydrouracil dehydrogenase (NAD+)
Systematic name
5,6-dihydropyrimidine:NAD+ oxidoreductase
CAS registry number
9026-89-5
Comment
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6].
History
created 1961, modified 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.3.1.23 created 1972, deleted 2005 1.3.1.50 created 1992, deleted 1999 1.3.1.55 created 1999, deleted 2004 1.3.2.1 created 1961, deleted 1964 1.3.2.2 created 1961, deleted 1964
