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EC 1.17.99.10 Details
EC number
1.17.99.10
Accepted name
steroid C-25 hydroxylase
Reaction
cholest-4-en-3-one + acceptor + H2O = 25-hydroxycholest-4-en-3-one + reduced acceptor
Other name(s)
s25dA1 (gene name),
s25dA1B3 (gene name),
s25dA1C3 (gene name),
cholesterol C-25 dehydrogenase,
steroid C-25 dehydrogenase
Systematic name
cholest-4-en-3-one:acceptor oxidoreductase (25-hydroxylating)
Comment
The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol. The enzyme can accept several substrates including vitamin D3. The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38, cholesterol 25-monooxygenase, an oxygen-requiring eukaryotic enzyme that catalyses a similar transformation.
History
created 2020
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