EC Explorer
[browse EC tree] - [search]
EC 1.5.3.16 Details
EC number
1.5.3.16
Accepted name
spermine oxidase
Reaction
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2
Other name(s)
PAOh1/SMO,
PAOh1 (ambiguous),
AtPAO1,
AtPAO4,
SMO,
mSMO,
SMO(PAOh1),
SMO/PAOh1,
SMO5,
mSMOmu
Systematic name
spermidine:oxygen oxidoreductase (spermidine-forming)
Comment
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase).
History
created 2009
EC Tree
1.5.3.3 created 1961, deleted 1972
1.5.3.8 created 1989, deleted 1992
1.5.3.9 created 1989, modified 1999, deleted 2002