2.7.1.48: uridine/cytidine kinase
This is an abbreviated version!
For detailed information about uridine/cytidine kinase, go to the full flat file.
Word Map on EC 2.7.1.48
-
2.7.1.48
-
thymidine
-
salvage
-
uracil
-
phosphoribosyltransferase
-
phosphorylase
-
orotate
-
ump
-
5-fluorouracil
-
5-fluorouridine
-
deoxycytidine
-
5-azacytidine
-
6-azauridine
-
3-deazauridine
-
orotidine
-
pyrazofurin
-
medicine
-
5-fluoro-2'-deoxyuridine
-
3huridine
-
dihydrouracil
-
drug development
-
diagnostics
-
biotechnology
- 2.7.1.48
- thymidine
-
salvage
- uracil
-
phosphoribosyltransferase
- phosphorylase
- orotate
- ump
- 5-fluorouracil
- 5-fluorouridine
- deoxycytidine
- 5-azacytidine
- 6-azauridine
- 3-deazauridine
- orotidine
- pyrazofurin
- medicine
- 5-fluoro-2'-deoxyuridine
-
3huridine
- dihydrouracil
- drug development
- diagnostics
- biotechnology
Reaction
Synonyms
ATP:uridine 5'-phosphotransferase, hsUCK2, kinase, uridine (phosphorylating), More, pyrimidine ribonucleoside kinase, ttCK, UCK, UCK1, UCK2, UCKL1, Udk, UK/UPRT1, uridine cytidine kinase 2, uridine kinase, uridine phosphokinase, uridine-cytidine kinase, uridine-cytidine kinase 2, uridine/cytidine kinase, uridine/cytidine kinase 2
ECTree
2.7.1.48 uridine/cytidine kinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.1.48 - uridine/cytidine kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
ADP + 3'-ethynylcytidine 5'-monophosphate
-
-
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate
ATP + 3'-deoxy-3'-ethynylcytidine
ADP + 3'-deoxy-3'-ethynylcytidine 5'-monophosphate
-
recombinant uridine kinase, 20% of activity with uridine
-
?
ATP + 3'-deoxy-3'-ethynyluridine
ADP + 3'-deoxy-3'-ethynyluridine 5'-monophosphate
-
recombinant uridine kinase, 20% of activity with uridine
-
?
ATP + 3'-ethynylcytidine
ADP + 3'-ethynylcytidine 5'-monophosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
-
-
?
ATP + 3'-ethynylcytidine 5'-diphosphate
ADP + 3'-ethynylcytidine 5'-triphosphate
-
-
-
?
ATP + 3'-ethynylcytidine 5'-monophosphate
ADP + 3'-ethynylcytidine 5'-diphosphate
-
-
-
?
ATP + 3'-ethynyluridine
ADP + 3'-ethynyluridine 5'-monophosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
-
-
?
ATP + 3'-ethynyluridine 5'-diphosphate
ADP + 3'-ethynyluridine 5'-triphosphate
-
-
-
?
ATP + 3'-ethynyluridine 5'-monophosphate
ADP + 3'-ethynyluridine 5'-diphosphate
-
-
-
?
ATP + 3-methyluridine
ADP + 3-methyluridine 5'-monophosphate
recombinant uridine kinase 2, 18% of activity with uridine
-
?
ATP + 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1H)-one
ADP + [(3S,4S,5R)-3-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-fluoro-4,5-dihydroxycyclopent-1-en-1-yl]methyl phosphate
-
-
-
ir
ATP + 5-fluorouridine
ADP + 5-fluoro-uridine monophosphate
-
-
-
?
ATP + cyclopentenyl-cytosine
ADP + cyclopentenylcytosine 5'-monophosphate
-
-
-
?
ATP + cyclopentenylcytosine
ADP + cyclopentenylcytosine 5'-monophosphate
-
recombinant uridine kinase, 12% of activity with uridine
-
?
ATP + fluorocyclopentenylcytosine
?
an orally available cytidine analogue, RX-3117
-
-
?
ATP + N4-aminocytidine
ADP + N4-aminocytidine 5'-monophosphate
recombinant uridine kinase 1, 20% of activity with uridine
-
?
ATP + ribavirin
ADP + ribavirin monophosphate
-
13% of substrate phosphorylated, within 2 h incubation
-
-
?
GTP + 5-fluorocytidine
GDP + 5-fluorocytidine 5'-monophosphate
-
40% of activity with uridine
-
?
GTP + 5-fluorouridine
GDP + 5-fluorouridine 5'-monophosphate
-
60% of activity with uridine
-
?
GTP + 6-azauridine
GDP 6-azauridine 5'-monophosphate
-
31% of activity with uridine
-
?
GTP + N-acetylcytidine
GDP + N-acetylcytidine 5'-monophosphate
-
57% of activity with uridine
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate
-
-
-
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine 5'-phosphate
-
UCK2 enzyme activity required to produce the antitumoral active metabolite
-
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate
-
-
-
-
?
ATP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
ADP + 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine 5'-phosphate
-
UCK2 enzyme activity required to produce the antitumoral active metabolite
-
-
?
ATP + 2-thiocytidine
ADP + 2-thiocytidine 5'-monophosphate
recombinant uridine kinase 2, 86% of activity with uridine
-
?
ATP + 2-thiocytidine
ADP + 2-thiocytidine 5'-monophosphate
recombinant uridine kinase 1, 20% of activity with uridine
-
?
ATP + 3'-C-ethynylcytidine
ADP + 3'-C-ethynylcytidine 5'-phosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
-
-
ir
ATP + 3'-C-ethynylcytidine
ADP + 3'-C-ethynylcytidine 5'-phosphate
-
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine
-
-
ir
ATP + 3'-C-ethynylcytidine 5'-diphosphate
ADP + 3'-C-ethynylcytidine 5'-triphosphate
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-diphosphate
ADP + 3'-C-ethynylcytidine 5'-triphosphate
-
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-phosphate
ADP + 3'-C-ethynylcytidine 5'-diphosphate
-
-
-
?
ATP + 3'-C-ethynylcytidine 5'-phosphate
ADP + 3'-C-ethynylcytidine 5'-diphosphate
-
-
-
-
?
ATP + 3'-C-ethynyluridine
ADP + 3'-C-ethynyluridine 5'-phosphate
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
-
-
?
ATP + 3'-C-ethynyluridine
ADP + 3'-C-ethynyluridine 5'-phosphate
-
i.e. 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine
-
-
?
ATP + 3'-C-ethynyluridine 5'-diphosphate
ADP + 3'-C-ethynyluridine 5'-triphosphate
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-diphosphate
ADP + 3'-C-ethynyluridine 5'-triphosphate
-
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-phosphate
ADP + 3'-C-ethynyluridine 5'-diphosphate
-
-
-
?
ATP + 3'-C-ethynyluridine 5'-phosphate
ADP + 3'-C-ethynyluridine 5'-diphosphate
-
-
-
-
?
ATP + 3,4,5,6-tetrahydrouridine
ADP + 3,4,5,6-tetrahydrouridine 5'-monophosphate
recombinant uridine kinase 1, 13% of activity with uridine
-
?
ATP + 3,4,5,6-tetrahydrouridine
ADP + 3,4,5,6-tetrahydrouridine 5'-monophosphate
recombinant uridine kinase 2, 81% of activity with uridine
-
?
ATP + 3-deazauridine
ADP + 3-deazauridine 5'-monophosphate
recombinant uridine kinase 2, 49% of activity with uridine
-
?
ATP + 4-thiouridine
ADP + 4-thiouridine 5'-monophosphate
recombinant uridine kinase 1, 122% of activity with uridine
-
?
ATP + 4-thiouridine
ADP + 4-thiouridine 5'-monophosphate
recombinant uridine kinase 2, 125% of activity with uridine
-
?
ATP + 5-azacytidine
ADP + 5-azacytidine 5'-monophosphate
-
39.1% of the activity with uridine
-
?
ATP + 5-bromouridine
ADP + 5-bromouridine 5'-monophosphate
recombinant uridine kinase 1, 50% of activity with uridine
-
?
ATP + 5-bromouridine
ADP + 5-bromouridine 5'-monophosphate
recombinant uridine kinase 2,6% of activity with uridine
-
?
ATP + 5-fluorocytidine
ADP + 5-fluorocytidine 5'-monophosphate
recombinant uridine kinase 1, 37% of activity with uridine
-
?
ATP + 5-fluorocytidine
ADP + 5-fluorocytidine 5'-monophosphate
recombinant uridine kinase 2, 184% of activity with uridine
-
?
ATP + 5-fluorouridine
ADP + 5-fluorouridine 5'-monophosphate
-
recombinant uridine kinase
-
?
ATP + 5-fluorouridine
ADP + 5-fluorouridine 5'-monophosphate
recombinant uridine kinase 2, 89% of activity with uridine
-
?
ATP + 5-fluorouridine
ADP + 5-fluorouridine 5'-monophosphate
-
66.9% of the activity with uridine
-
?
ATP + 5-hydroxyuridine
ADP + 5-hydroxyuridine 5'-monophosphate
recombinant uridine kinase 1, 14% of activity with uridine
-
?
ATP + 5-hydroxyuridine
ADP + 5-hydroxyuridine 5'-monophosphate
recombinant uridine kinase 2, 12% of activity with uridine
-
?
ATP + 5-methoxyuridine
ADP + 5-methoxyuridine 5'-monophosphate
recombinant uridine kinase 1, 122% of activity with uridine
-
?
ATP + 5-methoxyuridine
ADP + 5-methoxyuridine 5'-monophosphate
recombinant uridine kinase 2, 92% of activity with uridine
-
?
ATP + 5-methylcytidine
ADP + 5-methylcytidine 5'-monophosphate
recombinant uridine kinase 1, 9% of activity with uridine
-
?
ATP + 5-methylcytidine
ADP + 5-methylcytidine 5'-monophosphate
recombinant uridine kinase 2, 30% of activity with uridine
-
?
ATP + 6-azacytidine
ADP + 6-azacytidine 5'-monophosphate
recombinant uridine kinase 2, 75% of activity with uridine
-
?
ATP + 6-azacytidine
ADP + 6-azacytidine 5'-monophosphate
-
60.4% of the activity with uridine
-
?
ATP + 6-azauridine
ADP + 6-azauridine 5'-monophosphate
recombinant uridine kinase 1, 38% of activity with uridine, recombinant uridine kinase 2, 148% of activity with uridine
-
?
ATP + 6-azauridine
ADP + 6-azauridine 5'-monophosphate
-
65.5% of the activity with uridine
-
?
ATP + CMP
ADP + CDP
-
low activity with ATP as phosphate donor
-
-
?
ATP + CMP
ADP + CDP
-
low activity with ATP as phosphate donor
-
-
?
ATP + cytidine
ADP + CMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + cytidine
ADP + CMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + cytidine
ADP + CMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation
-
-
?
ATP + cytidine
ADP + CMP
-
89% of substrate phosphorylated, within 2 h incubation
-
-
?
ATP + cytidine
ADP + CMP
the enzyme is responsible for the phosphorylation of uridine and cytidine to their corresponding monophosphate in a salvage pathway of pyrimidine nucleotides biosynthesis
-
-
?
ATP + cytidine
ADP + CMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + N4-acetylcytidine
ADP + N4-acetylcytidine 5'-monophosphate
recombinant uridine kinase 1, 142% of activity with uridine
-
?
ATP + N4-acetylcytidine
ADP + N4-acetylcytidine 5'-monophosphate
recombinant uridine kinase 2, 84% of activity with uridine
-
?
ATP + N4-anisoylcytidine
ADP + N4-anisoylcytidine 5'-monophosphate
recombinant uridine kinase 2, 12% of activity with uridine
-
?
ATP + N4-anisoylcytidine
ADP + N4-anisoylcytidine 5'-monophosphate
recombinant uridine kinase 1, 20% of activity with uridine
-
?
ATP + N4-benzoylcytidine
ADP + N4-benzoylcytidine 5'-monophosphate
recombinant uridine kinase 1, 68% of activity with uridine
-
?
ATP + N4-benzoylcytidine
ADP + N4-benzoylcytidine 5'-monophosphate
recombinant uridine kinase 2, 51% of activity with uridine
-
?
ATP + UMP
ADP + UDP
-
low activity with ATP as phosphate donor
-
-
?
ATP + UMP
ADP + UDP
-
low activity with ATP as phosphate donor
-
-
?
ATP + uridine
ADP + UMP
-
dGTP and GTP are the most efficient phosphate donors, activity with ATP and dATP is 10% and with dUTP, dCTP and dTTP 5% of that with GTP or dGTP
-
?
ATP + uridine
ADP + UMP
-
very low activity with CTP and UTP
-
?
ATP + uridine
ADP + UMP
-
first enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
no activity with adenosine, guanosine and deoxyribonucleotides, no activity with CTP and UTP
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway, essential for cell proliferation, UCK 2 involved in tumor formation
-
-
?
ATP + uridine
ADP + UMP
-
56% of substrate phosphorylated, within 2 h incubation
-
-
?
ATP + uridine
ADP + UMP
the enzyme is responsible for the phosphorylation of uridine and cytidine to their corresponding monophosphate in a salvage pathway of pyrimidine nucleotides biosynthesis
-
-
?
ATP + uridine
ADP + UMP
-
no activity with thymine riboside, deoxyribosides, cytosine arabinoside, adenosine, purine deoxyribosides, UMP, CMP and deoxyribosides
-
?
ATP + uridine
ADP + UMP
-
no activity with thymine riboside, deoxyribosides, cytosine arabinoside, adenosine, purine deoxyribosides, UMP, CMP and deoxyribosides
-
?
ATP + uridine
ADP + UMP
-
enzyme is part of the anabolic pathway by which the preformed pyrimidine nucleosides are salvaged for nucleic acid biosynthesis
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
-
rate-limiting enzyme in anabolism of uridine and cytidine
-
?
ATP + uridine
ADP + UMP
-
rate limiting enzyme of the pyrimidine-nucleotide salvage pathway
-
-
?
ATP + uridine
ADP + UMP
-
first enzyme of pyrimidine salvage pathway
-
?
ATP + uridine
ADP + UMP
substrate of mutant ttCKs Y93H and Y93Q, not of wild-type ttCK Y93
-
-
?
ATP + uridine
ADP + UMP
reaction of ttCK enzyme mutants Y93H and Y93Q only, no activity with the wild-type enzyme
-
-
?
ATP + uridine
ADP + UMP
reaction of ttCK enzyme mutants Y93H and Y93Q only, no activity with the wild-type enzyme
-
-
?
ATP + uridine
ADP + UMP
reaction of ttCK enzyme mutants Y93H and Y93Q only, no activity with the wild-type enzyme
-
-
?
ATP + uridine
ADP + UMP
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
substrate of mutant ttCKs Y93H and Y93Q, not of wild-type ttCK Y93
-
-
?
CTP + CMP
CDP + CDP
-
low activity with CTP as phosphate donor
-
-
?
CTP + UMP
CDP + UDP
-
low activity with CTP as phosphate donor
-
-
?
GTP + CMP
GDP + CDP
-
GTP is the best phosphate donor
-
-
?
GTP + UMP
CDP + UDP
-
GTP is the best phosphate donor
-
-
?
GTP + uridine
GDP + UMP
-
GTP is the best phosphate donor
-
-
?
uridine + ATP
UMP + ADP
with GTP: 25% activity, with UTP or CTP: 0% activity
-
-
?
UTP + CMP
UDP + CDP
-
low activity with UTP as phosphate donor
-
-
?
UTP + UMP
UDP + UDP
-
low activity with UTP as phosphate donor
-
-
?
additional information
?
-
-
it is ineffective to use ATP, UTP or CTP as the phosphate donor
-
-
?
additional information
?
-
uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine, cytidine, and several pyrimidine ribonucleoside analogues
-
-
-
additional information
?
-
uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine, cytidine, and several pyrimidine ribonucleoside analogues
-
-
-
additional information
?
-
-
uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine, cytidine, and several pyrimidine ribonucleoside analogues
-
-
-
additional information
?
-
-
it is ineffective to use ATP, UTP or CTP as the phosphate donor
-
-
?
additional information
?
-
-
it is ineffective to use ATP, UTP or CTP as the phosphate donor
-
-
?
additional information
?
-
-
uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis
-
-
?
additional information
?
-
molecular mechanisms of substrate specificities of uridine-cytidine kinase, overview
-
-
-
additional information
?
-
molecular mechanisms of substrate specificities of uridine-cytidine kinase, overview
-
-
-
additional information
?
-
molecular mechanisms of substrate specificities of uridine-cytidine kinase, overview
-
-
-
