2.6.1.19: 4-aminobutyrate-2-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about 4-aminobutyrate-2-oxoglutarate transaminase, go to the full flat file.

Reaction

Synonyms

4-aminobutyrate aminotransferase, 4-aminobutyrate transaminase, 4-aminobutyrate-2-ketoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate transaminase, 4-aminobutyric acid 2-ketoglutaric acid aminotransferase, 4-aminobutyric acid aminotransferase, ABAT, aminobutyrate aminotransferase, aminobutyrate transaminase, aminotransferase, aminobutyrate, argD, argD6803, argD7002, Atu3000, beta-alanine aminotransferase, beta-alanine transaminase, beta-alanine-oxoglutarate aminotransferase, beta-alanine-oxoglutarate transaminase, bioA, CG010_026395, CgGABA-AT, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-2-oxoglutarate aminotransferase, GABA-2-oxoglutarate transaminase, GABA-alpha-ketoglutarate aminotransferase, GABA-alpha-ketoglutarate transaminase, GABA-alpha-ketoglutaric acid transaminase, GABA-alpha-oxoglutarate aminotransferase, GABA-AT, GABA-oxoglutarate aminotransferase, GABA-oxoglutarate transaminase, GABA-T, GABA-T1, GABA-T2, GABA-T3, GABA-TA, GABA-transaminase, GABA:2-oxoglutarate aminotransferase, GABAT, GabT, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate aminotransferase, gamma-aminobutyrate transaminase, gamma-aminobutyrate transaminases, gamma-aminobutyrate-alpha-ketoglutarate aminotransferase, gamma-aminobutyrate-alpha-ketoglutarate transaminase, gamma-aminobutyrate: GABA transaminase, gamma-aminobutyrate:alpha-oxoglutarate aminotransferase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric acid-2-oxoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase, gamma-aminobutyric transaminase, gatT, glutamate-succinic semialdehyde transaminase, homotaurine:2-oxoglutarate aminotransferase, MdGABA-T1, MdGABA-T2, More, NCgl0462, NCgl2515, Osl2, pollen-pistil incompatibility 2, Pop2, SkUga1p, slr1022

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase

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Results	in table
1	Activating Compound
11867	AA Sequence
8	Application
1	CAS Registry Number
24	Cloned(Commentary)
57	Cofactor
12	Crystallization (Commentary)
680	Disease/ Diagnostics
7	Expression
85	General Information
3	General Stability
10	IC50 Value
264	Inhibitors
16	kcat/KM [mM/s]
61	Ki Value [mM]
114	KM Value [mM]
35	Localization
3	Metals/Ions
42	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
165	Organism
17	Pathway
105	PDB ID
38	pH Optimum
13	pH Range
4	pH Stability
2	pI Value
48	Protein Variants
26	Purification (Commentary)
10	Reaction
1	Reaction Type
151	Reference
3	Renatured (Commentary)
115	Source Tissue
60	Specific Activity [micromol/min/mg]
5	Storage Stability
275	Substrates and Products (Substrate)
24	Subunits
268	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
6	Temperature Range [°C]
22	Temperature Stability [°C]
46	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.1

1-(4-acetylphenyl)-3-(4-bromophenyloxy)-pyrrolidine-2,5-dione

Mus musculus

P61922

pH 7.5, 37°C

738910

0.16

1-(4-acetylphenyl)-3-(salicyldehydroxy)-pyrrolidine-2,5-dione

Mus musculus

P61922

pH 7.5, 37°C

738910

0.00399

3-chloro-1-(4-hydroxyphenyl)propan-1-one

Homo sapiens

-

-

702606

0.0165

4-hydroxybenzaldehyde

2 entries

0.0154

4-hydroxybenzylamine

Homo sapiens

-

IC50: 0.0154 mM, competitive inhibition

672609

0.0018

gabaculine

Rattus norvegicus

-

IC50: 0.0018 mM, potent and irreversible inhibitor

675524

0.086

N-(4-bromophenyl)-3-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide

Sus scrofa

P80147

predicted value, pH not specified in the publication, temperature not specified in the publication

738027

0.149

N-(4-bromophenyl)-3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydroindeno[1,2-c]pyrazole-2(3H)-carboxamide

Sus scrofa

P80147

predicted value, pH not specified in the publication, temperature not specified in the publication

738027

0.35

vigabatrin

Rattus norvegicus

-

IC50: 0.35 mM

675524

0.0165

4-hydroxybenzaldehyde

Homo sapiens

-

-

702606

0.0165

4-hydroxybenzaldehyde

Homo sapiens

-

IC50: 0.0165 mM, competitive inhibition

672609