2.5.1.132: 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

This is an abbreviated version!
For detailed information about 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.132

2.5.1.132

n-acetylneuraminic

sialic

deaminoneuraminic

pep

testis

man-6-p

Reaction

3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate

Synonyms

2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase, 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase, 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase, BT1714, KDN 9-phosphate synthase, KDN-9-P synthase, KDN-9-phosphate synthetase, KDN-9P synthase, N-acetylneuraminic acid phosphate synthase, Neu5Ac 9-phosphate synthase, neu5ac-9-P synthase, NeuNAc-9-P synthase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.132 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

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Results	in table
2	AA Sequence
3	Cloned(Commentary)
2	Disease/ Diagnostics
2	Inhibitors
4	kcat/KM [mM/s]
5	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
7	Organism
3	Pathway
3	pH Optimum
4	Protein Variants
4	Purification (Commentary)
1	Reaction
7	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Turnover Number [1/s]

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Reference on EC 2.5.1.132 - 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

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671868

Hao, J.; Vann, W.F.; Hinderlich, S.; Sundaramoorthy, M.

Elimination of 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation

Biochem. J.

397

195-201

2006

Homo sapiens

16503877

685801

Reaves, M.L.; Lopez, L.C.; Daskalova, S.M.

Replacement of the antifreeze-like domain of human N-acetylneuraminic acid phosphate synthase with the mouse antifreeze-like domain impacts both N-acetylneuraminic acid 9-phosphate synthase and 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activities

BMB rep.

72-78

2008

Homo sapiens

18304454

736395

Angata, T.; Nakata, D.; Matsuda, T.; Kitajima, K.; Troy, F.A.

Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis

J. Biol. Chem.

274

22949-22956

1999

Oncorhynchus mykiss

10438460

737585

Angata, T.; Nakata, D.; Matsuda, T.; Kitajima, K.

Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media

Biochem. Biophys. Res. Commun.

261

326-331

1999

Chlorocebus aethiops, Mus musculus

10425185

738039

Wang, L.; Lu, Z.; Allen, K.; Mariano, P.; Dunaway-Mariano, D.

Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)

Chem. Biol.

893-897

2008

Bacteroides thetaiotaomicron (Q8A711)

18804026

738566

Lawrence, S.M.; Huddleston, K.A.; Pitts, L.R.; Nguyen, N.; Lee, Y.C.; Vann, W.F.; Coleman, T.A.; Betenbaugh, M.J.

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability

J. Biol. Chem.

275

17869-17877

2000

Homo sapiens (Q9NR45)

10749855