isoform Fta allows synthesis of H type 2 and H type 3 histo-blood group antigen epitopes at the cell surface. In Chinese hamster ovary cells transfected by FTA, FTA is able to synthesize H type 2 epitopes on a large set of glycoproteins
transfected human DNA sequences in mouse L-cells determine expression of the (alpha-1,2)fucosyltransferases in the mouse transfectants. Primary transfectants express cell surface type II blood group H antigen and (alpha-l,2)fucosyltransferase activity
on allergen inhalation, lung epithelial cells are heavily alpha(1,2)fucosylated by Fut2, which is induced by the IL-13-signal transducer and activator of transcription 6 pathway. Fut2-deficient mice lack lung epithelial fucosylation and show significantly attenuated eosinophilic inflammation and airway hyperresponsiveness in house dust mite-induced asthma models. Complement C3 is accumulated in fucosylated areas. Fut2-/- mice show significantly reduced levels of C3a and impaired accumulation of C3a receptor-expressing monocyte-derived dendritic cells in the lung on house dust mite challenge