2.4.1.335: dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase

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Word Map on EC 2.4.1.335

2.4.1.335

coagulation

bleed

anticoagulant

thromboplastin

padua

fvii:c

arg304gln

hemophilia

rivaroxaban

fvii-deficient

Reaction

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate

an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate

an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate

Synonyms

AglC, Mv990, UDP-Glc-2,3-diNAcA glycosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.335 dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase

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Results	in table
23	AA Sequence
1	Cloned(Commentary)
2	General Information
2	Localization
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
1	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.1.335 - dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase

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UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate:dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase

The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.