2.4.1.258: dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase
This is an abbreviated version!
For detailed information about dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.258
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2.4.1.258
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n-glycosylation
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n-glycans
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lipid-linked
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oligosaccharide
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glc3man9glcnac2
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glycan
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medicine
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peptide-n-glycosidase
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synthesis
- 2.4.1.258
-
n-glycosylation
- n-glycans
-
lipid-linked
- oligosaccharide
- glc3man9glcnac2
- glycan
- medicine
-
peptide-n-glycosidase
- synthesis
Reaction
Synonyms
Alg3, Alg3p, AtALG3, Dol-P-Man:Man5GlcNAc2-PP-Dol alpha1,3-mannosyl transferase, Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase, dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase, EC 2.4.1.130, Not56-like protein, PpAlg3 alpha-1,3-mannosyl transferase, TbALG3
ECTree
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Systematic Name
Systematic Name on EC 2.4.1.258 - dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase
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dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-mannosyltransferase
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3.