2.4.1.201: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.201

2.4.1.201

5-phosphate

1-deoxy-d-xylulose

fosmidomycin

isoprenoids

valine

falciparum

methylerythritol

reductoisomerase

isoleucine

n-glycans

1-deoxyxylulose

mtdna

Reaction

beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta-1,4-, VI, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta-1-4-, VI, GCNT6, GnT VI, GnT-VI, mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, Mgat6, N-acetylglucosaminyltransferase VI, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI, UDP-GlcNAc: GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man] beta1-4N-acetylglucosaminyltransferase VI, UDP-GlcNAc:GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha-R (GlcNAc to Man) beta4-GlcNAc-transferase VI, UDP-GlcNAc:GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man]beta1-4N-acetylglucosaminyltransferase VI, UDP-N-acetyl-D-glucosamine (GlcNAc):GlcNAcbeta1-6(GlcNAcbeta1-2)-Manalpha1-R[GlcNAc to Man]beta1,4N-acetylglucosaminyltransferase VI, uridine diphosphoacetylglucosamine-glycopeptide beta-1-4-acetylglucosaminyltransferase VI

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.201 alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

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Results	in table
5	Activating Compound
26	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
3	General Information
2	General Stability
7	Inhibitors
2	KM Value [mM]
4	Localization
47	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
2	Pathway
6	pH Optimum
2	pH Range
2	Posttranslational Modification
1	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
16	Reference
14	Source Tissue
3	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
3	Subunits
21	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.1.201 - alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

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UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->2)]-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages. No homologous enzyme appears to exist in mammals.