2.4.1.182: lipid-A-disaccharide synthase

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For detailed information about lipid-A-disaccharide synthase, go to the full flat file.

Word Map on EC 2.4.1.182

2.4.1.182

acyltransferase

raetz

clockwise

udp-glcnac

lipopolysaccharide

paralogue

lps

udp-2,3-diacylglucosamine

castellanii

cotranscribed

amoebae

micelle

pneumophila

bacteriol

acanthamoeba

glycerophospholipids

resin

udp-n-acetylglucosamine

synthesis

Reaction

a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine

Synonyms

lcsC, lcsC/lpxB1, Legionella cytotoxic suppressor C, lipid A disaccharide synthase, lipid A disaccharide synthetase, LpxB, More, pgsB, synthase, lipid A disaccharide

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.182 lipid-A-disaccharide synthase

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Results	in table
6	Activating Compound
26409	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
18	General Information
2	Inhibitors
3	KM Value [mM]
15	Localization
1	Metals/Ions
12	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
25	Organism
11	Pathway
4	PDB ID
7	pH Optimum
1	pH Range
21	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
23	Reference
7	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
11	Subunits
35	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

Crystallization

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Crystallization on EC 2.4.1.182 - lipid-A-disaccharide synthase

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purified soluble recombinant enzymes, LpxB in the apo form and bound to UDP: LpxB7S, SeMet-LpxB7S, LpxB7S with UDP, and mutant LpxB6S (V66S/V68S/L69S/L72S/L75S/L76S), the ligand-bound structure of LpxB is obtained by soaking crystals with 10mM UDP-N-acytlglucosamine (UDP-GlcNAc), X-ray diffraction structure determination and analysis at 1.98-3.43 A resolution

Escherichia coli

P10441

759836