2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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For detailed information about galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, go to the full flat file.

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Synonyms

beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, GlcATI, GlcUAT-I, glucuronosyltransferase I, glucuronyltransferase-I, glycosaminoglycan glucuronyltransferase I, glycosyltransferases GlcAT1, UDP-GlcUA:Gal Beta-1,3-Gal-R glucuronyltransferase, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, UDP-glucuronic acid:Galbeta1,3Gal-R glucuronsyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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Results	in table
4376	AA Sequence
2	CAS Registry Number
14	Cloned(Commentary)
4	Crystallization (Commentary)
16	Disease/ Diagnostics
5	Expression
6	General Information
4	Inhibitors
31	KM Value [mM]
7	Localization
12	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
24	Organism
7	Pathway
12	PDB ID
4	pH Optimum
1	pH Range
1	Posttranslational Modification
37	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
30	Source Tissue
2	Specific Activity [micromol/min/mg]
56	Substrates and Products (Substrate)
3	Subunits
34	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Disease

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Disease on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Bicuspid Aortic Valve Disease

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.

21763480

Chlamydia Infections

Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.

22675117

Fasciculation

Nutritionally driven differential gene expression leads to heterochronic brain development in honeybee castes.

23738002

Heart Septal Defects, Ventricular

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.

21763480

Idiopathic Pulmonary Fibrosis

Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of ?1,3-glucuronosyltransferase I in pulmonary fibrosis.

21056957

Mitral Valve Prolapse

Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.

21763480

Neuroinflammatory Diseases

Tumor necrosis factor-alpha up-regulates glucuronosyltransferase gene expression in human brain endothelial cells and promotes T-cell adhesion.

17335072

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