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additional information
in-silico structural analysis and molecular docking. Three dimensional structure and binding mode of sinapate with SGT enzyme, overview
evolution
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the enzyme belongs to the glycosyltransferase-B type superfamily
evolution
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the enzyme belongs to the glycosyltransferase-B type superfamily
malfunction
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silencing the gene of UDP-glucose:sinapate glucosyltransferase (UGT84A9) reduces the anti-nutritive properties of the seeds by lowering the content of the major seed component sinapine (sinapoylcholine) and various minor sinapate esters. Silencing of UGT84A9 gene expression disrupt the metabolic flow through sinapoylglucose and alters the amounts and nature of the phenylpropanoid endproducts
malfunction
suppression of the key biosynthetic enzyme UDP-glucose:sinapic acid glucosyltransferase (UGT84A9) inhibits the biosynthesis of sinapine (sinapoylcholine), the major phenolic component of seeds. Suppression of the major sink pathway of sinapic acid impacts the metabolome of developing seeds and seedlings in UGT84A9-suppressing (UGT84A9i) lines, massive alterations become evident in late stages of seed development affecting the accumulation levels of 58 secondary and 7 primary metabolites, e.g. decreased amounts of various hydroxycinnamic acid esters, and increased formation of sinapic and syringic acid glycosides, overview. Suppression of UGT84A9 under control of the seed-specific NAPINC promoter is maintained in cotyledons during the first two weeks of seedling development and associated with a reduced and delayed transformation of sinapine into sinapoylmalate
metabolism
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in the 1-O-sinapoylglucose biosynthesis pathway, Sinapic acid and UDP-glucose act as potential substrates for the UDP-glucose: sinapic acid glucosyltransferase, which catalyzes the transfer of glucose moiety from UDP-glucose to the 1-O-position of sinapic acid
metabolism
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in the 1-O-sinapoylglucose biosynthesis pathway, Sinapic acid and UDP-glucose act as potential substrates for the UDP-glucose: sinapic acid glucosyltransferase, which catalyzes the transfer of glucose moiety from UDP-glucose to the 1-O-position of sinapic acid
metabolism
SGT and SCT, encoding enzymes UDP-glucose: sinapate glucosyltransferase and sinapoylglucose: choline sinapoyltransferase, respectively, are involved in the final two steps of sinapine biosynthetic pathway. Comparison of the two enzymes, overview
physiological function
key enzyme for sinapate ester biosynthesis, the glucosyltransferase UGT84A9 catalyzes the formation of 1-O-sinapoyl-D-glucose, which feeds as acyl donor into a broad range of accumulating sinapate esters, including the major antinutritive seed component sinapoylcholine (sinapine)
physiological function
key enzyme for sinapate ester biosynthesis, the glucosyltransferase UGT84A9 catalyzes the formation of 1-O-sinapoyl-D-glucose, which feeds as acyl donor into a broad range of accumulating sinapate esters, including the major antinutritive seed component sinapoylcholine (sinapine)
physiological function
the enzyme is involved in glycosylation and beta-oxidation as metabolic detoxification strategies to bypass intracellular accumulation of sinapic acid. Feedback regulation of hydroxycinnamic acid biosynthesis
physiological function
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UDP-glucose: sinapic acid glucosyltransferase (USAGT1) from Daucus carota may influence anthocyanin biosynthesis of purple carrot taproots, DcUSAGT1 may play important roles in the stability of anthocyanin accumulation
physiological function
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UDP-glucose: sinapic acid glucosyltransferase (USAGT1) from Daucus carota may influence anthocyanin biosynthesis of purple carrot taproots, DcUSAGT1 may play important roles in the stability of anthocyanin accumulation