2.3.1.289: aureothin polyketide synthase system
This is an abbreviated version!
For detailed information about aureothin polyketide synthase system, go to the full flat file.
Reaction
+ + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+ = + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
Synonyms
aurABC, aureothin polyketide synthase complex
ECTree
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General Information
General Information on EC 2.3.1.289 - aureothin polyketide synthase system
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physiological function
Q70KH8; Q70KH5; Q70KH4
comparison of Stretomyces thiolueus aureothin and Streptomyces orinoci neoaureothin gene clusters and enzymes. In both cases individual polyketide synthase modules are used in an iterative fashion
physiological function
Q70KH8; Q70KH5; Q70KH4
heterologous expression of an engineered AurAB fusion protein. Inactivation the ketosynthase or acyl carrier domains of module 4 clearly result in a shutdown of polyketide biosynthesis. Module 4 is required for the biosynthesis of polyketide production, and, despite the apparently inactive AT4 domain, an iterative use of the entirety of module 3 seems not to take place
physiological function
Q70KH8; Q70KH5; Q70KH4
model of the itinerative action of polyketide synthase. The ACP-bound polyketide intermediate is transferred back to the ketosynthase domain on the opposite polyketide synthase strand. the AurA N-terminus is not involved in the iteration process
physiological function
Q70KH8; Q70KH5; Q70KH4
the aureothin biosynthetic gene cluster is composed of 4 modules and is encoded by three genes. The enzyme extends 4-nitrobenzoyl-CoA by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules
physiological function
Streptomyces thioluteus HKI-227
-
the aureothin biosynthetic gene cluster is composed of 4 modules and is encoded by three genes. The enzyme extends 4-nitrobenzoyl-CoA by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules
-
physiological function
Streptomyces thioluteus HKI-227
-
heterologous expression of an engineered AurAB fusion protein. Inactivation the ketosynthase or acyl carrier domains of module 4 clearly result in a shutdown of polyketide biosynthesis. Module 4 is required for the biosynthesis of polyketide production, and, despite the apparently inactive AT4 domain, an iterative use of the entirety of module 3 seems not to take place
-
physiological function
Streptomyces thioluteus HKI-227
-
comparison of Stretomyces thiolueus aureothin and Streptomyces orinoci neoaureothin gene clusters and enzymes. In both cases individual polyketide synthase modules are used in an iterative fashion
-
physiological function
Streptomyces thioluteus HKI-227
-
model of the itinerative action of polyketide synthase. The ACP-bound polyketide intermediate is transferred back to the ketosynthase domain on the opposite polyketide synthase strand. the AurA N-terminus is not involved in the iteration process
-