2.3.1.221: noranthrone synthase
This is an abbreviated version!
For detailed information about noranthrone synthase, go to the full flat file.
Word Map on EC 2.3.1.221
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2.3.1.221
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sporopollenin
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tetraketide
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exine
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anther
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microspore
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tapetal
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reductase1
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halogenase
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prenyltransferase
- 2.3.1.221
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sporopollenin
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tetraketide
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exine
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anther
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microspore
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tapetal
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reductase1
- halogenase
- prenyltransferase
Reaction
7 malonyl-CoA + = 7 CoA + + + 7 CO2 + 2 H2O
Synonyms
norsolorinic acid anthrone synthase, norsolorinic acid anthrone-producing polyketide synthase, PksA, polyketide synthase A
ECTree
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Substrates Products
Substrates Products on EC 2.3.1.221 - noranthrone synthase
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REACTION DIAGRAM
7 malonyl-CoA + hexanoyl-[acyl-carrier protein]
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
additional information
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processivity of polyketide extension and substrate specificity, overview. The enzyme shows activity against hexanoyl- and acetyl-, but not malonyl-CoA. Rapid loading of extension units onto the carrier domain facilitates efficient chain extension in a manner kinetically favorable to ultimate product formation. Essential roles of the product template and thioesterase domains for cyclization and product release, editing role for the thioesterase domain
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7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
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7 malonyl-CoA + hexanoyl-[acyl-carrier protein]
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
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ACP-bound intermediates and major products of the reaction, overview
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7 malonyl-CoA + hexanoyl-[acyl-carrier protein]
7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
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