2.3.1.207: beta-ketodecanoyl-[acyl-carrier-protein] synthase
This is an abbreviated version!
For detailed information about beta-ketodecanoyl-[acyl-carrier-protein] synthase, go to the full flat file.
Reaction
Synonyms
beta-ketoacyl synthase, FabY, PA3286 protein
ECTree
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General Information
General Information on EC 2.3.1.207 - beta-ketodecanoyl-[acyl-carrier-protein] synthase
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malfunction
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the fabY deletion strain grows slowly in comparison to the fabHEc exchange control without C10 supplementation
metabolism
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the KASIII domain-containing enzyme FabY from open reading frame PA3286 shunts fatty acid degradation intermediates from the beta-oxidation pathway by condensing octanoyl-CoA with malonyl-ACP to make beta-keto-decanoyl-ACP, a key building block common to saturated fatty acids, unsaturated fatty acids, and lipopolysaccharides
physiological function
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FabY, a beta-ketoacyl synthase KASI/II domain-containing enzyme that condenses acetyl-CoA with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis, FAS, primer beta-acetoacetyl-ACP. FabY is an enzyme required for FAS initiation in the absence of exogenous fatty acids