2.1.1.368: [histone H3]-lysine9 N-dimethyltransferase

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For detailed information about [histone H3]-lysine9 N-dimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.368

2.1.1.368

suvar3-9

chromatin

rna-directed

heterochromatinization

methyltransferases

monomethylated

heterochromatic

chromatin-remodeling

redundantly

trimethylation

transposable

hmtases

heterochromatin-specific

dosage-dependent

chromocenter

microrchidia

dnaj

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

Synonyms

EHMT1, EHMT2, G9a, GLP, H3 lysine-9 specific histone-lysine N-methyltransferase, KMT1C, KMT1D, SDG32, SET1, SET13, SET32, SUVH1, SuvH2, SUVR1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.368 [histone H3]-lysine9 N-dimethyltransferase

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Results	in table
7	AA Sequence
8	General Information
1	Inhibitors
8	kcat/KM [mM/s]
8	KM Value [mM]
1	Localization
2	Natural Substrates/ Products (Substrates)
9	Organism
2	Pathway
3	Reaction
8	Reference
2	Source Tissue
9	Substrates and Products (Substrate)
18	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.368 - [histone H3]-lysine9 N-dimethyltransferase

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S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-dimethyltransferase

This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.